Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks

Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks

Here the authors fuse hRad51 and variants thereof to Cas9 nickase to facilitate homology-directed repair without generating double strand breaks, minimizing indel formation and off-target editing. This tool represents progress towards the goal of performing HDR without an excess of undesired side pr...

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Autores principales: Holly A. Rees, Wei-Hsi Yeh, David R. Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/be483dddb5c54b75a6dd4f6fc308c2d2
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