TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.

A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into...

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Autores principales:	Christian B Lindstad, Alisa E Dewan, Jorunn Stamnaes, Ludvig M Sollid, M Fleur du Pré
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be49347ce9df44428d5f10923a025e4f
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spelling	oai:doaj.org-article:be49347ce9df44428d5f10923a025e4f2021-12-02T20:04:28ZTG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.1932-620310.1371/journal.pone.0259082https://doaj.org/article/be49347ce9df44428d5f10923a025e4f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259082https://doaj.org/toc/1932-6203A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4+ T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities.Christian B LindstadAlisa E DewanJorunn StamnaesLudvig M SollidM Fleur du PréPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259082 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian B Lindstad Alisa E Dewan Jorunn Stamnaes Ludvig M Sollid M Fleur du Pré TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.
description	A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4+ T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities.
format	article
author	Christian B Lindstad Alisa E Dewan Jorunn Stamnaes Ludvig M Sollid M Fleur du Pré
author_facet	Christian B Lindstad Alisa E Dewan Jorunn Stamnaes Ludvig M Sollid M Fleur du Pré
author_sort	Christian B Lindstad
title	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.
title_short	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.
title_full	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.
title_fullStr	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.
title_full_unstemmed	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.
title_sort	tg2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific b cells in celiac disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/be49347ce9df44428d5f10923a025e4f
work_keys_str_mv	AT christianblindstad tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT alisaedewan tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT jorunnstamnaes tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT ludvigmsollid tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT mfleurdupre tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease
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TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.

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