Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Here, the authors show that inhibition of PMIF may have translational benefits for managing malaria infections.

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Autores principales:	Alvaro Baeza Garcia, Edwin Siu, Tiffany Sun, Valerie Exler, Luis Brito, Armin Hekele, Gib Otten, Kevin Augustijn, Chris J. Janse, Jeffrey B. Ulmer, Jürgen Bernhagen, Erol Fikrig, Andrew Geall, Richard Bucala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be49eab245d7481c9136ee80bc91bed8
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spelling	oai:doaj.org-article:be49eab245d7481c9136ee80bc91bed82021-12-02T14:39:24ZNeutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection10.1038/s41467-018-05041-72041-1723https://doaj.org/article/be49eab245d7481c9136ee80bc91bed82018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05041-7https://doaj.org/toc/2041-1723Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Here, the authors show that inhibition of PMIF may have translational benefits for managing malaria infections.Alvaro Baeza GarciaEdwin SiuTiffany SunValerie ExlerLuis BritoArmin HekeleGib OttenKevin AugustijnChris J. JanseJeffrey B. UlmerJürgen BernhagenErol FikrigAndrew GeallRichard BucalaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alvaro Baeza Garcia Edwin Siu Tiffany Sun Valerie Exler Luis Brito Armin Hekele Gib Otten Kevin Augustijn Chris J. Janse Jeffrey B. Ulmer Jürgen Bernhagen Erol Fikrig Andrew Geall Richard Bucala Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
description	Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Here, the authors show that inhibition of PMIF may have translational benefits for managing malaria infections.
format	article
author	Alvaro Baeza Garcia Edwin Siu Tiffany Sun Valerie Exler Luis Brito Armin Hekele Gib Otten Kevin Augustijn Chris J. Janse Jeffrey B. Ulmer Jürgen Bernhagen Erol Fikrig Andrew Geall Richard Bucala
author_facet	Alvaro Baeza Garcia Edwin Siu Tiffany Sun Valerie Exler Luis Brito Armin Hekele Gib Otten Kevin Augustijn Chris J. Janse Jeffrey B. Ulmer Jürgen Bernhagen Erol Fikrig Andrew Geall Richard Bucala
author_sort	Alvaro Baeza Garcia
title	Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
title_short	Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
title_full	Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
title_fullStr	Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
title_full_unstemmed	Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
title_sort	neutralization of the plasmodium-encoded mif ortholog confers protective immunity against malaria infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/be49eab245d7481c9136ee80bc91bed8
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Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

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