Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.

Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.

Selenium is an essential trace element and selenoprotein N (SelN) was the first selenium-containing protein shown to be directly involved in human inherited diseases. Mutations in the SEPN1 gene, encoding SelN, cause a group of muscular disorders characterized by predominant affection of axial muscl...

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Main Authors: Mathieu Rederstorff, Perrine Castets, Sandrine Arbogast, Jeanne Lainé, Stéphane Vassilopoulos, Maud Beuvin, Odile Dubourg, Alban Vignaud, Arnaud Ferry, Alain Krol, Valérie Allamand, Pascale Guicheney, Ana Ferreiro, Alain Lescure
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/be4eb237517f44e19d3891ab804ea5cd
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https://doaj.org/article/be4eb237517f44e19d3891ab804ea5cd

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