Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion

Arief S Kartasasmita, Siska Takarai, Astriviani Switania, Sutarya Enus Department of Ophthalmology, Universitas Padjadjaran/Cicendo National Eye Hospital, Bandung, Indonesia Background: Macular grid laser photocoagulation remains the standard treatment for macular edema secondary to branch retinal...

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Autores principales:	Kartasasmita AS, Takarai S, Switania A, Enus S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Bevacizumab Branch retinal vein occlusion Grid laser photocoagulation Macular edema Vascular endothelial growth factor. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/be504b32f81445e5b192d46648868adb
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spelling	oai:doaj.org-article:be504b32f81445e5b192d46648868adb2021-12-02T04:41:51ZEfficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion1177-5483https://doaj.org/article/be504b32f81445e5b192d46648868adb2016-10-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-single-bevacizumab-injection-as-adjuvant-therapy-to-laser--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Arief S Kartasasmita, Siska Takarai, Astriviani Switania, Sutarya Enus Department of Ophthalmology, Universitas Padjadjaran/Cicendo National Eye Hospital, Bandung, Indonesia Background: Macular grid laser photocoagulation remains the standard treatment for macular edema secondary to branch retinal vein occlusion (BRVO). One possible strategy for treating macular edema is to inhibit VEGF activity by competitive binding of VEGF with an anti-VEGF antibody, suggesting the therapy option with bevacizumab. However, multiple injections of anti-VEGF may lead to complications and high cost. Purpose: The aim of this study was to evaluate the improvement in visual acuity and central macular thickness after combination therapy of laser photocoagulation with single intravitreal bevacizumab injection in macular edema secondary to BRVO. Methods: Nineteen patients with macular edema secondary to BRVO were assigned to either the group of nine patients in combination therapy of laser photocoagulation with intravitreal bevacizumab or the group of ten patients in the laser photocoagulation therapy. Complete ophthalmologic examinations were performed just before the therapy and at 1 month following the therapy. Changes in visual acuity were tested with the logarithm of minimum angle of resolution (logMAR), and central macular thickness was measured by optical coherence tomography (OCT). Results: Combination therapy of laser photocoagulation and single intravitreal bevacizumab injection resulted in a significantly better visual acuity compared to laser photocoagulation therapy (0.35 versus 0.13 logMAR; P=0.041) and reduced macular thickness by 120.33 µm versus 71.50 µm (P=0.277), although this difference was not significant. Conclusion: Laser photocoagulation combined with a single intravitreal bevacizumab has a substantial effect on increasing visual acuity in macular edema secondary to BRVO. Keywords: bevacizumab, branch retinal vein occlusion, grid laser photocoagulation, macular edema, vascular endothelial growth factorKartasasmita ASTakarai SSwitania AEnus SDove Medical PressarticleBevacizumabBranch retinal vein occlusionGrid laser photocoagulationMacular edemaVascular endothelial growth factor.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 2135-2140 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bevacizumab Branch retinal vein occlusion Grid laser photocoagulation Macular edema Vascular endothelial growth factor. Ophthalmology RE1-994
spellingShingle	Bevacizumab Branch retinal vein occlusion Grid laser photocoagulation Macular edema Vascular endothelial growth factor. Ophthalmology RE1-994 Kartasasmita AS Takarai S Switania A Enus S Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion
description	Arief S Kartasasmita, Siska Takarai, Astriviani Switania, Sutarya Enus Department of Ophthalmology, Universitas Padjadjaran/Cicendo National Eye Hospital, Bandung, Indonesia Background: Macular grid laser photocoagulation remains the standard treatment for macular edema secondary to branch retinal vein occlusion (BRVO). One possible strategy for treating macular edema is to inhibit VEGF activity by competitive binding of VEGF with an anti-VEGF antibody, suggesting the therapy option with bevacizumab. However, multiple injections of anti-VEGF may lead to complications and high cost. Purpose: The aim of this study was to evaluate the improvement in visual acuity and central macular thickness after combination therapy of laser photocoagulation with single intravitreal bevacizumab injection in macular edema secondary to BRVO. Methods: Nineteen patients with macular edema secondary to BRVO were assigned to either the group of nine patients in combination therapy of laser photocoagulation with intravitreal bevacizumab or the group of ten patients in the laser photocoagulation therapy. Complete ophthalmologic examinations were performed just before the therapy and at 1 month following the therapy. Changes in visual acuity were tested with the logarithm of minimum angle of resolution (logMAR), and central macular thickness was measured by optical coherence tomography (OCT). Results: Combination therapy of laser photocoagulation and single intravitreal bevacizumab injection resulted in a significantly better visual acuity compared to laser photocoagulation therapy (0.35 versus 0.13 logMAR; P=0.041) and reduced macular thickness by 120.33 µm versus 71.50 µm (P=0.277), although this difference was not significant. Conclusion: Laser photocoagulation combined with a single intravitreal bevacizumab has a substantial effect on increasing visual acuity in macular edema secondary to BRVO. Keywords: bevacizumab, branch retinal vein occlusion, grid laser photocoagulation, macular edema, vascular endothelial growth factor
format	article
author	Kartasasmita AS Takarai S Switania A Enus S
author_facet	Kartasasmita AS Takarai S Switania A Enus S
author_sort	Kartasasmita AS
title	Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion
title_short	Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion
title_full	Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion
title_fullStr	Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion
title_full_unstemmed	Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion
title_sort	efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/be504b32f81445e5b192d46648868adb
work_keys_str_mv	AT kartasasmitaas efficacyofsinglebevacizumabinjectionasadjuvanttherapytolaserphotocoagulationinmacularedemasecondarytobranchretinalveinocclusion AT takarais efficacyofsinglebevacizumabinjectionasadjuvanttherapytolaserphotocoagulationinmacularedemasecondarytobranchretinalveinocclusion AT switaniaa efficacyofsinglebevacizumabinjectionasadjuvanttherapytolaserphotocoagulationinmacularedemasecondarytobranchretinalveinocclusion AT enuss efficacyofsinglebevacizumabinjectionasadjuvanttherapytolaserphotocoagulationinmacularedemasecondarytobranchretinalveinocclusion
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Efficacy of single bevacizumab injection as adjuvant therapy to laser photocoagulation in macular edema secondary to branch retinal vein occlusion

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