Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth

The aim of the study was to evaluate inflammatory tissue reactions and the formation of calcified tissue after implantation of experimental nanostructured calcium silicate cement (CS) and hydroxyapatite with calcium silicate cement (HA-CS) into root canals of rabbits’ teeth. The study was conducted...

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Autores principales:	Violeta Petrović, Vanja Opačić-Galić, Vukoman Jokanović, Jelena Sopta, Bolka Prokić Bogomir, Slavoljub Živković
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	biocompatibility calcium silicate hard tissue formation hydroxyapatite Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/be521b2d915a490db88da634c31d81ac
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spelling	oai:doaj.org-article:be521b2d915a490db88da634c31d81ac2021-11-17T21:27:54ZHistological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth1820-744810.2478/acve-2021-0006https://doaj.org/article/be521b2d915a490db88da634c31d81ac2021-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2021-0006https://doaj.org/toc/1820-7448The aim of the study was to evaluate inflammatory tissue reactions and the formation of calcified tissue after implantation of experimental nanostructured calcium silicate cement (CS) and hydroxyapatite with calcium silicate cement (HA-CS) into root canals of rabbits’ teeth. The study was conducted on four rabbits of the genus Oryctolagus cuniculus. After instrumentation and irrigation, the root canals of the central incisors were dried and filled with CS, HA-CS and control material (MTA Angelus). The animals were sacrificed after 28 days. After histological preparation and hematoxylin-eosin staining, tissue samples were evaluated for the intensity and extension of inflammatory tissue reaction; continuity, morphology and thickness of the newly formed calcified tissue; and presence of giant cells, materials particles and microorganisms. Kruskal Wallis and Dunn’s post hoc test were used for data analysis (α=0.05). There were no significant differences in the intensity of inflammatory reactions between CS, HA-CS and MTA control. HA-CS showed significantly better results than MTA and CS with respect to continuity of the newly formed calcified tissue (P=0.003 and P=0.010, respectively). Significant differences in thickness of the calcified tissue existed between CS and MTA (P=0.004) and between HA-CS and MTA (P=0.012). Application of CS and HA-CS resulted in minimal inflammatory tissue response, similar to the MTA control. CS and HA-CS were more efficient than MTA in supporting hard tissue formation. The best organized newly formed calcified tissue was seen after HA-CS application.Violeta PetrovićVanja Opačić-GalićVukoman JokanovićJelena SoptaBolka Prokić BogomirSlavoljub ŽivkovićSciendoarticlebiocompatibilitycalcium silicatehard tissue formationhydroxyapatiteVeterinary medicineSF600-1100ENActa Veterinaria, Vol 71, Iss 1, Pp 85-97 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biocompatibility calcium silicate hard tissue formation hydroxyapatite Veterinary medicine SF600-1100
spellingShingle	biocompatibility calcium silicate hard tissue formation hydroxyapatite Veterinary medicine SF600-1100 Violeta Petrović Vanja Opačić-Galić Vukoman Jokanović Jelena Sopta Bolka Prokić Bogomir Slavoljub Živković Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth
description	The aim of the study was to evaluate inflammatory tissue reactions and the formation of calcified tissue after implantation of experimental nanostructured calcium silicate cement (CS) and hydroxyapatite with calcium silicate cement (HA-CS) into root canals of rabbits’ teeth. The study was conducted on four rabbits of the genus Oryctolagus cuniculus. After instrumentation and irrigation, the root canals of the central incisors were dried and filled with CS, HA-CS and control material (MTA Angelus). The animals were sacrificed after 28 days. After histological preparation and hematoxylin-eosin staining, tissue samples were evaluated for the intensity and extension of inflammatory tissue reaction; continuity, morphology and thickness of the newly formed calcified tissue; and presence of giant cells, materials particles and microorganisms. Kruskal Wallis and Dunn’s post hoc test were used for data analysis (α=0.05). There were no significant differences in the intensity of inflammatory reactions between CS, HA-CS and MTA control. HA-CS showed significantly better results than MTA and CS with respect to continuity of the newly formed calcified tissue (P=0.003 and P=0.010, respectively). Significant differences in thickness of the calcified tissue existed between CS and MTA (P=0.004) and between HA-CS and MTA (P=0.012). Application of CS and HA-CS resulted in minimal inflammatory tissue response, similar to the MTA control. CS and HA-CS were more efficient than MTA in supporting hard tissue formation. The best organized newly formed calcified tissue was seen after HA-CS application.
format	article
author	Violeta Petrović Vanja Opačić-Galić Vukoman Jokanović Jelena Sopta Bolka Prokić Bogomir Slavoljub Živković
author_facet	Violeta Petrović Vanja Opačić-Galić Vukoman Jokanović Jelena Sopta Bolka Prokić Bogomir Slavoljub Živković
author_sort	Violeta Petrović
title	Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth
title_short	Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth
title_full	Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth
title_fullStr	Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth
title_full_unstemmed	Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth
title_sort	histological evaluation of periradicular tissue inflammatory reactions and calcified tissue formations after implantation of experimental calcium silicate and hydroxyapatite based nanostructural cements into root canals of rabbits teeth
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/be521b2d915a490db88da634c31d81ac
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Histological Evaluation of Periradicular Tissue Inflammatory Reactions and Calcified Tissue Formations After Implantation of Experimental Calcium Silicate and Hydroxyapatite Based Nanostructural Cements Into Root Canals of Rabbits Teeth

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