Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children

Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children

Yakob Gebregziabher Tsegay,1,* Agerie Tadele,2 Zelalem Addis,3 Agersew Alemu,4 Mulugeta Melku2,* 1Bahir Dar Regional Health Research Laboratory Center, Bahir Dar, 2Department of Hematology and Immunohematology, 3Department of Medical Microbiology, 4Department of Medical Parasitology, School of Biome...

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Autores principales: Tsegay YG, Tadele A, Addis Z, Alemu A, Melku M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Anemia
Children
Cytopenia
HAART
HIV
Leukopenia
Neutropenia
Pacytopenia
Thrombocytopenia
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/be5483f7b5af48dab596fe55696c640f
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spelling oai:doaj.org-article:be5483f7b5af48dab596fe55696c640f2021-12-02T01:37:36ZMagnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children1179-1373https://doaj.org/article/be5483f7b5af48dab596fe55696c640f2017-02-01T00:00:00Zhttps://www.dovepress.com/magnitude-of-cytopenias-among-hivinfected-children-in-bahir-dar-northw-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Yakob Gebregziabher Tsegay,1,* Agerie Tadele,2 Zelalem Addis,3 Agersew Alemu,4 Mulugeta Melku2,* 1Bahir Dar Regional Health Research Laboratory Center, Bahir Dar, 2Department of Hematology and Immunohematology, 3Department of Medical Microbiology, 4Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia *These authors contributed equally to this work Background: AIDS, caused by HIV, is a multisystem disease that affects hematopoiesis. The aim of this study was to assess cytopenias among HIV-infected children who had a follow-up at Felege Hiwot Referral Hospital, Bahir Dar, northwest Ethiopia. Methods: An institution-based cross-sectional study was conducted between April and May 2013. Systematic random sampling method was used to select the study participants. Descriptive statistics, independent t-test as well as chi-square and logistic regression were used for analysis. A p-value <0.05 was considered as statistically significant. Results: A total of 224 children (112 highly active antiretroviral therapy [HAART]-naïve and 112 HAART-experienced) participated in the study. The magnitude of anemia, thrombocytopenia, neutropenia, leukopenia and pancytopenia among HAART-naïve HIV-infected children were 30.4%, 9.8%, 8%, 4.5% and 1.8%, respectively. The overall prevalence of anemia, neutropenia, thrombocytopenia, leukopenia and pancytopenia were 29.5%, 8.9%, 8%, 4.5% and 1.4%, respectively. Cluster of differentiation-4 percentage and mean corpuscular volume were significantly different between HAART-experienced and HAART-naïve children. Being of younger age and severely immunosuppressed were risk factors of anemia. Conclusion: Anemia was the most common cytopenia, followed by neutropenia. Severe immunosuppression and younger age were significantly associated with anemia. Therefore, emphasis should be given for investigation and management of cytopenias in HIV-infected children, particularly for those who are immunosuppressed and of younger age. Keywords: anemia, children, cytopenia, HAART, HIV, leukopenia, neutropenia, pancytopenia, thrombocytopeniaTsegay YGTadele AAddis ZAlemu AMelku MDove Medical PressarticleAnemiaChildrenCytopeniaHAARTHIVLeukopeniaNeutropeniaPacytopeniaThrombocytopeniaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 9, Pp 31-42 (2017)
institution DOAJ
collection DOAJ
language EN
topic Anemia
Children
Cytopenia
HAART
HIV
Leukopenia
Neutropenia
Pacytopenia
Thrombocytopenia
Immunologic diseases. Allergy
RC581-607
spellingShingle Anemia
Children
Cytopenia
HAART
HIV
Leukopenia
Neutropenia
Pacytopenia
Thrombocytopenia
Immunologic diseases. Allergy
RC581-607
Tsegay YG
Tadele A
Addis Z
Alemu A
Melku M
Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children
description Yakob Gebregziabher Tsegay,1,* Agerie Tadele,2 Zelalem Addis,3 Agersew Alemu,4 Mulugeta Melku2,* 1Bahir Dar Regional Health Research Laboratory Center, Bahir Dar, 2Department of Hematology and Immunohematology, 3Department of Medical Microbiology, 4Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia *These authors contributed equally to this work Background: AIDS, caused by HIV, is a multisystem disease that affects hematopoiesis. The aim of this study was to assess cytopenias among HIV-infected children who had a follow-up at Felege Hiwot Referral Hospital, Bahir Dar, northwest Ethiopia. Methods: An institution-based cross-sectional study was conducted between April and May 2013. Systematic random sampling method was used to select the study participants. Descriptive statistics, independent t-test as well as chi-square and logistic regression were used for analysis. A p-value <0.05 was considered as statistically significant. Results: A total of 224 children (112 highly active antiretroviral therapy [HAART]-naïve and 112 HAART-experienced) participated in the study. The magnitude of anemia, thrombocytopenia, neutropenia, leukopenia and pancytopenia among HAART-naïve HIV-infected children were 30.4%, 9.8%, 8%, 4.5% and 1.8%, respectively. The overall prevalence of anemia, neutropenia, thrombocytopenia, leukopenia and pancytopenia were 29.5%, 8.9%, 8%, 4.5% and 1.4%, respectively. Cluster of differentiation-4 percentage and mean corpuscular volume were significantly different between HAART-experienced and HAART-naïve children. Being of younger age and severely immunosuppressed were risk factors of anemia. Conclusion: Anemia was the most common cytopenia, followed by neutropenia. Severe immunosuppression and younger age were significantly associated with anemia. Therefore, emphasis should be given for investigation and management of cytopenias in HIV-infected children, particularly for those who are immunosuppressed and of younger age. Keywords: anemia, children, cytopenia, HAART, HIV, leukopenia, neutropenia, pancytopenia, thrombocytopenia
format article
author Tsegay YG
Tadele A
Addis Z
Alemu A
Melku M
author_facet Tsegay YG
Tadele A
Addis Z
Alemu A
Melku M
author_sort Tsegay YG
title Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children
title_short Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children
title_full Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children
title_fullStr Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children
title_full_unstemmed Magnitude of cytopenias among HIV‑infected children in Bahir Dar, northwest Ethiopia: a comparison of HAART-naïve and HAART‑experienced children
title_sort magnitude of cytopenias among hiv‑infected children in bahir dar, northwest ethiopia: a comparison of haart-naïve and haart‑experienced children
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/be5483f7b5af48dab596fe55696c640f
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