Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice
How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.
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Nature Portfolio
2021
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oai:doaj.org-article:be579d8154684279867ebaa15847607e2021-12-02T19:02:28ZExcitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice10.1038/s41467-021-25356-22041-1723https://doaj.org/article/be579d8154684279867ebaa15847607e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25356-2https://doaj.org/toc/2041-1723How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.Eunee LeeSeungjoon LeeJae Jin ShinWoochul ChoiChanguk ChungSuho LeeJihye KimSeungmin HaRyunhee KimTaesun YooYe-Eun YooJisoo KimYoung Woo NohIssac RhimSoo Yeon LeeWoohyun KimTaekyung LeeHyogeun ShinIl-Joo ChoKarl DeisserothSang Jeong KimJoo Min ParkMin Whan JungSe-Bum PaikEunjoon KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
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Science Q Eunee Lee Seungjoon Lee Jae Jin Shin Woochul Choi Changuk Chung Suho Lee Jihye Kim Seungmin Ha Ryunhee Kim Taesun Yoo Ye-Eun Yoo Jisoo Kim Young Woo Noh Issac Rhim Soo Yeon Lee Woohyun Kim Taekyung Lee Hyogeun Shin Il-Joo Cho Karl Deisseroth Sang Jeong Kim Joo Min Park Min Whan Jung Se-Bum Paik Eunjoon Kim Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice |
| description |
How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour. |
| format |
article |
| author |
Eunee Lee Seungjoon Lee Jae Jin Shin Woochul Choi Changuk Chung Suho Lee Jihye Kim Seungmin Ha Ryunhee Kim Taesun Yoo Ye-Eun Yoo Jisoo Kim Young Woo Noh Issac Rhim Soo Yeon Lee Woohyun Kim Taekyung Lee Hyogeun Shin Il-Joo Cho Karl Deisseroth Sang Jeong Kim Joo Min Park Min Whan Jung Se-Bum Paik Eunjoon Kim |
| author_facet |
Eunee Lee Seungjoon Lee Jae Jin Shin Woochul Choi Changuk Chung Suho Lee Jihye Kim Seungmin Ha Ryunhee Kim Taesun Yoo Ye-Eun Yoo Jisoo Kim Young Woo Noh Issac Rhim Soo Yeon Lee Woohyun Kim Taekyung Lee Hyogeun Shin Il-Joo Cho Karl Deisseroth Sang Jeong Kim Joo Min Park Min Whan Jung Se-Bum Paik Eunjoon Kim |
| author_sort |
Eunee Lee |
| title |
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice |
| title_short |
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice |
| title_full |
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice |
| title_fullStr |
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice |
| title_full_unstemmed |
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice |
| title_sort |
excitatory synapses and gap junctions cooperate to improve pv neuronal burst firing and cortical social cognition in shank2-mutant mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/be579d8154684279867ebaa15847607e |
| work_keys_str_mv |
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