Mathematical Models of Plasmid Population Dynamics

With plasmid-mediated antibiotic resistance thriving and threatening to become a serious public health problem, it is paramount to increase our understanding of the forces that enable the spread and maintenance of drug resistance genes encoded in mobile genetic elements. The relevance of plasmids as...

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Autores principales:	José Carlos Ramón Hernández-Beltrán, Alvaro San Millán, Ayari Fuentes-Hernández, Rafael Peña-Miller
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mathematical modeling horizontal gene transfer microbial ecology bacterial evolution plasmid dynamics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/be581ed7cbe14db6bedb0cd57562654a
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spelling	oai:doaj.org-article:be581ed7cbe14db6bedb0cd57562654a2021-11-04T09:33:09ZMathematical Models of Plasmid Population Dynamics1664-302X10.3389/fmicb.2021.606396https://doaj.org/article/be581ed7cbe14db6bedb0cd57562654a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.606396/fullhttps://doaj.org/toc/1664-302XWith plasmid-mediated antibiotic resistance thriving and threatening to become a serious public health problem, it is paramount to increase our understanding of the forces that enable the spread and maintenance of drug resistance genes encoded in mobile genetic elements. The relevance of plasmids as vehicles for the dissemination of antibiotic resistance genes, in addition to the extensive use of plasmid-derived vectors for biotechnological and industrial purposes, has promoted the in-depth study of the molecular mechanisms controlling multiple aspects of a plasmids’ life cycle. This body of experimental work has been paralleled by the development of a wealth of mathematical models aimed at understanding the interplay between transmission, replication, and segregation, as well as their consequences in the ecological and evolutionary dynamics of plasmid-bearing bacterial populations. In this review, we discuss theoretical models of plasmid dynamics that span from the molecular mechanisms of plasmid partition and copy-number control occurring at a cellular level, to their consequences in the population dynamics of complex microbial communities. We conclude by discussing future directions for this exciting research topic.José Carlos Ramón Hernández-BeltránAlvaro San MillánAyari Fuentes-HernándezRafael Peña-MillerFrontiers Media S.A.articlemathematical modelinghorizontal gene transfermicrobial ecologybacterial evolutionplasmid dynamicsMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mathematical modeling horizontal gene transfer microbial ecology bacterial evolution plasmid dynamics Microbiology QR1-502
spellingShingle	mathematical modeling horizontal gene transfer microbial ecology bacterial evolution plasmid dynamics Microbiology QR1-502 José Carlos Ramón Hernández-Beltrán Alvaro San Millán Ayari Fuentes-Hernández Rafael Peña-Miller Mathematical Models of Plasmid Population Dynamics
description	With plasmid-mediated antibiotic resistance thriving and threatening to become a serious public health problem, it is paramount to increase our understanding of the forces that enable the spread and maintenance of drug resistance genes encoded in mobile genetic elements. The relevance of plasmids as vehicles for the dissemination of antibiotic resistance genes, in addition to the extensive use of plasmid-derived vectors for biotechnological and industrial purposes, has promoted the in-depth study of the molecular mechanisms controlling multiple aspects of a plasmids’ life cycle. This body of experimental work has been paralleled by the development of a wealth of mathematical models aimed at understanding the interplay between transmission, replication, and segregation, as well as their consequences in the ecological and evolutionary dynamics of plasmid-bearing bacterial populations. In this review, we discuss theoretical models of plasmid dynamics that span from the molecular mechanisms of plasmid partition and copy-number control occurring at a cellular level, to their consequences in the population dynamics of complex microbial communities. We conclude by discussing future directions for this exciting research topic.
format	article
author	José Carlos Ramón Hernández-Beltrán Alvaro San Millán Ayari Fuentes-Hernández Rafael Peña-Miller
author_facet	José Carlos Ramón Hernández-Beltrán Alvaro San Millán Ayari Fuentes-Hernández Rafael Peña-Miller
author_sort	José Carlos Ramón Hernández-Beltrán
title	Mathematical Models of Plasmid Population Dynamics
title_short	Mathematical Models of Plasmid Population Dynamics
title_full	Mathematical Models of Plasmid Population Dynamics
title_fullStr	Mathematical Models of Plasmid Population Dynamics
title_full_unstemmed	Mathematical Models of Plasmid Population Dynamics
title_sort	mathematical models of plasmid population dynamics
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/be581ed7cbe14db6bedb0cd57562654a
work_keys_str_mv	AT josecarlosramonhernandezbeltran mathematicalmodelsofplasmidpopulationdynamics AT alvarosanmillan mathematicalmodelsofplasmidpopulationdynamics AT ayarifuenteshernandez mathematicalmodelsofplasmidpopulationdynamics AT rafaelpenamiller mathematicalmodelsofplasmidpopulationdynamics
_version_	1718444988851814400

Mathematical Models of Plasmid Population Dynamics

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