Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity

Abstract Background We investigated the role of ANGPTL3 and ANGPTL4 in atherosclerosis development and determined whether plasma concentrations of ANGPTL3 and ANGPTL4 are related to the degree of coronary stenosis. Methods A total of 305 consecutive patients with angina who underwent diagnostic coro...

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Autores principales: Ting Sun, Wanlin Zhan, Lijiang Wei, Zuojun Xu, Li Fan, Yang Zhuo, Changqian Wang, Junfeng Zhang
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Publicado: BMC 2021
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spelling oai:doaj.org-article:be5ac419e03b46528974ab9aee6939732021-11-08T11:16:06ZCirculating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity10.1186/s12944-021-01580-z1476-511Xhttps://doaj.org/article/be5ac419e03b46528974ab9aee6939732021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01580-zhttps://doaj.org/toc/1476-511XAbstract Background We investigated the role of ANGPTL3 and ANGPTL4 in atherosclerosis development and determined whether plasma concentrations of ANGPTL3 and ANGPTL4 are related to the degree of coronary stenosis. Methods A total of 305 consecutive patients with angina who underwent diagnostic coronary angiography were enrolled in the study between August 2017 and August 2018. The levels of ANGPTL3 and ANGPTL4 were measured by using competitive ELISA kits. Results According to the degree of coronary artery stenosis, patients were classified into four types: coronary artery stenosis of < 10%, 10-50%, 50-75, and > 75%. The plasma ANGPTL3 level was higher (51.71 ± 52.67 vs. 24.65 ± 10.32 ng/mL, P < 0.001) and that of ANGPTL4 was lower (454.66 ± 269.05 vs. 875.49 ± 961.15 ng/mL, P < 0.001) in the coronary artery stenosis ≥ 10% group than in the < 10% group. ANGPTL3 and ANGPTL4 levels were significantly associated with the severity of coronary vascular stenosis. ROC curve analyses indicated that ANGPTL3 concentrations above 30.5 ng/mL can predict atherosclerosis with a sensitivity of 71.2% and specificity of 75.3%, and that ANGPTL4 levels below 497.5 ng/mL can predict atherosclerosis with a sensitivity of 63.9% and specificity of 74.5%. ANGPTL3 and ANGPTL4 were determined to be independent risk factors for coronary atherosclerosis with odds ratios (ORs) of 0.189 (95% CI 0.097-0.368, P < 0.001) and 3.625 (95% CI 1.873-7.016, P < 0.001), respectively. Conclusions Increased ANGPTL3 or decreased ANGPTL4 shows an association with coronary atherosclerosis and, may become a predictor of coronary atherosclerosis in the future.Ting SunWanlin ZhanLijiang WeiZuojun XuLi FanYang ZhuoChangqian WangJunfeng ZhangBMCarticleANGPTL3ANGPTL4Coronary atherosclerosisPredictorsNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic ANGPTL3
ANGPTL4
Coronary atherosclerosis
Predictors
Nutritional diseases. Deficiency diseases
RC620-627
spellingShingle ANGPTL3
ANGPTL4
Coronary atherosclerosis
Predictors
Nutritional diseases. Deficiency diseases
RC620-627
Ting Sun
Wanlin Zhan
Lijiang Wei
Zuojun Xu
Li Fan
Yang Zhuo
Changqian Wang
Junfeng Zhang
Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity
description Abstract Background We investigated the role of ANGPTL3 and ANGPTL4 in atherosclerosis development and determined whether plasma concentrations of ANGPTL3 and ANGPTL4 are related to the degree of coronary stenosis. Methods A total of 305 consecutive patients with angina who underwent diagnostic coronary angiography were enrolled in the study between August 2017 and August 2018. The levels of ANGPTL3 and ANGPTL4 were measured by using competitive ELISA kits. Results According to the degree of coronary artery stenosis, patients were classified into four types: coronary artery stenosis of < 10%, 10-50%, 50-75, and > 75%. The plasma ANGPTL3 level was higher (51.71 ± 52.67 vs. 24.65 ± 10.32 ng/mL, P < 0.001) and that of ANGPTL4 was lower (454.66 ± 269.05 vs. 875.49 ± 961.15 ng/mL, P < 0.001) in the coronary artery stenosis ≥ 10% group than in the < 10% group. ANGPTL3 and ANGPTL4 levels were significantly associated with the severity of coronary vascular stenosis. ROC curve analyses indicated that ANGPTL3 concentrations above 30.5 ng/mL can predict atherosclerosis with a sensitivity of 71.2% and specificity of 75.3%, and that ANGPTL4 levels below 497.5 ng/mL can predict atherosclerosis with a sensitivity of 63.9% and specificity of 74.5%. ANGPTL3 and ANGPTL4 were determined to be independent risk factors for coronary atherosclerosis with odds ratios (ORs) of 0.189 (95% CI 0.097-0.368, P < 0.001) and 3.625 (95% CI 1.873-7.016, P < 0.001), respectively. Conclusions Increased ANGPTL3 or decreased ANGPTL4 shows an association with coronary atherosclerosis and, may become a predictor of coronary atherosclerosis in the future.
format article
author Ting Sun
Wanlin Zhan
Lijiang Wei
Zuojun Xu
Li Fan
Yang Zhuo
Changqian Wang
Junfeng Zhang
author_facet Ting Sun
Wanlin Zhan
Lijiang Wei
Zuojun Xu
Li Fan
Yang Zhuo
Changqian Wang
Junfeng Zhang
author_sort Ting Sun
title Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity
title_short Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity
title_full Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity
title_fullStr Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity
title_full_unstemmed Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity
title_sort circulating angptl3 and angptl4 levels predict coronary artery atherosclerosis severity
publisher BMC
publishDate 2021
url https://doaj.org/article/be5ac419e03b46528974ab9aee693973
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