Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR

Proliferative vitreoretinopathy(PVR)is a serious complication arisen from ocular trauma, diabetic retinopathy, vascular retinopathy, inflammatory retinopathy and other ocular diseases. It is also the most important reason for the failure of rhegmatogenous retinal detachment surgery, which is a great...

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Autores principales:	Hai-Yue Cui, Hong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	proliferative vitreoretinopathy(pvr) retinal pigment epithelial(rpe)cells proliferation migration epithelial-mesenchymal transition treatment Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/be647accf6944ccf8b6790484422819a
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spelling	oai:doaj.org-article:be647accf6944ccf8b6790484422819a2021-11-22T14:22:33ZResearch progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR1672-512310.3980/j.issn.1672-5123.2021.12.16https://doaj.org/article/be647accf6944ccf8b6790484422819a2021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112016.pdfhttps://doaj.org/toc/1672-5123Proliferative vitreoretinopathy(PVR)is a serious complication arisen from ocular trauma, diabetic retinopathy, vascular retinopathy, inflammatory retinopathy and other ocular diseases. It is also the most important reason for the failure of rhegmatogenous retinal detachment surgery, which is a great threat of visual function. A large number of studies have proved that the main risk factor for PVR is the damage of blood-retinal barrier, in which retinal pigment epithelial(RPE)cells are stimulated by cytokines in the vitreous cavity. RPE cells underwent epithelial-mesenchymal transition(EMT), which transformed into fibroblasts. The cell morphology changed, the tight junctions between cells disappeared, the cell polarity lost, and the proliferation, migration, and invasion abilities were enhanced. A contractile fibrous proliferative membrane is formed on the anterior surface or under the retina. The fibrous proliferative membrane will lead to the retina folds, pull the retina and lead to retinal detachment, which will eventually lead to vision loss or even blindness. Nowadays, plenty of studies investigating the prevention and treatment of PVR have been carried out at home and abroad. In this review, we briefly illustrated the signaling pathways related to epithelial-mesenchymal transformation in RPE cells and the treatment of PVR.Hai-Yue CuiHong LuPress of International Journal of Ophthalmology (IJO PRESS)articleproliferative vitreoretinopathy(pvr)retinal pigment epithelial(rpe)cellsproliferationmigrationepithelial-mesenchymal transitiontreatmentOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2104-2108 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	proliferative vitreoretinopathy(pvr) retinal pigment epithelial(rpe)cells proliferation migration epithelial-mesenchymal transition treatment Ophthalmology RE1-994
spellingShingle	proliferative vitreoretinopathy(pvr) retinal pigment epithelial(rpe)cells proliferation migration epithelial-mesenchymal transition treatment Ophthalmology RE1-994 Hai-Yue Cui Hong Lu Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR
description	Proliferative vitreoretinopathy(PVR)is a serious complication arisen from ocular trauma, diabetic retinopathy, vascular retinopathy, inflammatory retinopathy and other ocular diseases. It is also the most important reason for the failure of rhegmatogenous retinal detachment surgery, which is a great threat of visual function. A large number of studies have proved that the main risk factor for PVR is the damage of blood-retinal barrier, in which retinal pigment epithelial(RPE)cells are stimulated by cytokines in the vitreous cavity. RPE cells underwent epithelial-mesenchymal transition(EMT), which transformed into fibroblasts. The cell morphology changed, the tight junctions between cells disappeared, the cell polarity lost, and the proliferation, migration, and invasion abilities were enhanced. A contractile fibrous proliferative membrane is formed on the anterior surface or under the retina. The fibrous proliferative membrane will lead to the retina folds, pull the retina and lead to retinal detachment, which will eventually lead to vision loss or even blindness. Nowadays, plenty of studies investigating the prevention and treatment of PVR have been carried out at home and abroad. In this review, we briefly illustrated the signaling pathways related to epithelial-mesenchymal transformation in RPE cells and the treatment of PVR.
format	article
author	Hai-Yue Cui Hong Lu
author_facet	Hai-Yue Cui Hong Lu
author_sort	Hai-Yue Cui
title	Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR
title_short	Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR
title_full	Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR
title_fullStr	Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR
title_full_unstemmed	Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR
title_sort	research progress on the mechanism of epithelial mesenchymal transformation in rpe cells and the treatment of pvr
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/be647accf6944ccf8b6790484422819a
work_keys_str_mv	AT haiyuecui researchprogressonthemechanismofepithelialmesenchymaltransformationinrpecellsandthetreatmentofpvr AT honglu researchprogressonthemechanismofepithelialmesenchymaltransformationinrpecellsandthetreatmentofpvr
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Research progress on the mechanism of epithelial mesenchymal transformation in RPE cells and the treatment of PVR

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