Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients

Katsuhiko Maruyama,1 Asako Tsuchisaka,1 Jumpei Sakamoto,1 Shiroaki Shirato,2 Hiroshi Goto11Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 2Yotsuya Shirato Eye Clinic, Tokyo, JapanPurpose: To investigate the incidence of deepening of upper eyelid sulcus (DUES) with topical use o...

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Autores principales:	Maruyama K, Tsuchisaka A, Sakamoto J, Shirato S, Goto H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/be66cafe7db543898f321e015d502181
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spelling	oai:doaj.org-article:be66cafe7db543898f321e015d5021812021-12-02T04:38:32ZIncidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients1177-54671177-5483https://doaj.org/article/be66cafe7db543898f321e015d5021812013-07-01T00:00:00Zhttp://www.dovepress.com/incidence-of-deepening-of-upper-eyelid-sulcus-after-topical-use-of-taf-a13673https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Katsuhiko Maruyama,1 Asako Tsuchisaka,1 Jumpei Sakamoto,1 Shiroaki Shirato,2 Hiroshi Goto11Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 2Yotsuya Shirato Eye Clinic, Tokyo, JapanPurpose: To investigate the incidence of deepening of upper eyelid sulcus (DUES) with topical use of tafluprost in Japanese glaucoma patients.Methods: This study was a prospective, open-label, non-controlled case series conducted at a single center. Thirty-six primary open-angle glaucoma Japanese patients who had no history of surgery were enrolled. The patients were prescribed 0.0015% topical tafluprost once daily to one eye that had the more severe visual field disorder, and observed during outpatient visits before and at 30, 60, and 90 days after starting treatment. At every visit, three examiners judged the presence of DUES unanimously by facial photographs including eyebrows and lower eyelids. The primary outcome variable was the incidence of DUES at the end of day 90 in the study as assessed by observer-masked facial photography. The patients were also asked if they noticed any subjective symptom of DUES. Gender, refraction, and intraocular pressure were evaluated as potential risk factors.Results: Thirty-two patients completed this clinical trial. DUES were identified objectively in 19% (6/32) of the patients after 90 days of treatment. The incidence was not related to gender, refraction, baseline or post-treatment intraocular pressure, or intraocular pressure reduction. Finally, 17% (1/6) of patients with objectively diagnosed DUES noticed the presence of DUES by themselves. No patient dropped out of the study because of DUES.Conclusion: Similar to other prostaglandin analogs, topical use of tafluprost ophthalmic solution is associated with DUES as a local adverse reaction.Keywords: prostaglandins, tafluprost, eyelid, deepening, side effectMaruyama KTsuchisaka ASakamoto JShirato SGoto HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1441-1446 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Maruyama K Tsuchisaka A Sakamoto J Shirato S Goto H Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients
description	Katsuhiko Maruyama,1 Asako Tsuchisaka,1 Jumpei Sakamoto,1 Shiroaki Shirato,2 Hiroshi Goto11Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 2Yotsuya Shirato Eye Clinic, Tokyo, JapanPurpose: To investigate the incidence of deepening of upper eyelid sulcus (DUES) with topical use of tafluprost in Japanese glaucoma patients.Methods: This study was a prospective, open-label, non-controlled case series conducted at a single center. Thirty-six primary open-angle glaucoma Japanese patients who had no history of surgery were enrolled. The patients were prescribed 0.0015% topical tafluprost once daily to one eye that had the more severe visual field disorder, and observed during outpatient visits before and at 30, 60, and 90 days after starting treatment. At every visit, three examiners judged the presence of DUES unanimously by facial photographs including eyebrows and lower eyelids. The primary outcome variable was the incidence of DUES at the end of day 90 in the study as assessed by observer-masked facial photography. The patients were also asked if they noticed any subjective symptom of DUES. Gender, refraction, and intraocular pressure were evaluated as potential risk factors.Results: Thirty-two patients completed this clinical trial. DUES were identified objectively in 19% (6/32) of the patients after 90 days of treatment. The incidence was not related to gender, refraction, baseline or post-treatment intraocular pressure, or intraocular pressure reduction. Finally, 17% (1/6) of patients with objectively diagnosed DUES noticed the presence of DUES by themselves. No patient dropped out of the study because of DUES.Conclusion: Similar to other prostaglandin analogs, topical use of tafluprost ophthalmic solution is associated with DUES as a local adverse reaction.Keywords: prostaglandins, tafluprost, eyelid, deepening, side effect
format	article
author	Maruyama K Tsuchisaka A Sakamoto J Shirato S Goto H
author_facet	Maruyama K Tsuchisaka A Sakamoto J Shirato S Goto H
author_sort	Maruyama K
title	Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients
title_short	Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients
title_full	Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients
title_fullStr	Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients
title_full_unstemmed	Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients
title_sort	incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in japanese patients
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/be66cafe7db543898f321e015d502181
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Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients

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