21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.

21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.

Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also be a hormone that modulates epithelial cell adhesion. Cardiotonic steroids consist of a steroid nucleus and a lactone ring, and their biologi...

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Main Authors: Sayonarah C Rocha, Marco T C Pessoa, Luiza D R Neves, Silmara L G Alves, Luciana M Silva, Herica L Santos, Soraya M F Oliveira, Alex G Taranto, Moacyr Comar, Isabella V Gomes, Fabio V Santos, Natasha Paixão, Luis E M Quintas, François Noël, Antonio F Pereira, Ana C S C Tessis, Natalia L S Gomes, Otacilio C Moreira, Ruth Rincon-Heredia, Fernando P Varotti, Gustavo Blanco, Jose A F P Villar, Rubén G Contreras, Leandro A Barbosa
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/be6b9f94d29e4b688e9429a2fc67ac6a
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https://doaj.org/article/be6b9f94d29e4b688e9429a2fc67ac6a

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