Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions

Mammary epithelial cells are epigenetically modified during pregnancy, these changes can influence the pre-disposition to cancer. Here, the authors examine the epigenetic landscape of mammary epithelial cells pre and post pregnancy and identify changes to the epigenetic landscape, which can protect...

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Autores principales:	Mary J. Feigman, Matthew A. Moss, Chen Chen, Samantha L. Cyrill, Michael F. Ciccone, Marygrace C. Trousdell, Shih-Ting Yang, Wesley D. Frey, John E. Wilkinson, Camila O. dos Santos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be6daa3b32964ca8879edb8c33935d36
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spelling	oai:doaj.org-article:be6daa3b32964ca8879edb8c33935d362021-12-02T16:53:08ZPregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions10.1038/s41467-020-16479-z2041-1723https://doaj.org/article/be6daa3b32964ca8879edb8c33935d362020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16479-zhttps://doaj.org/toc/2041-1723Mammary epithelial cells are epigenetically modified during pregnancy, these changes can influence the pre-disposition to cancer. Here, the authors examine the epigenetic landscape of mammary epithelial cells pre and post pregnancy and identify changes to the epigenetic landscape, which can protect mice from Myc induced cancer.Mary J. FeigmanMatthew A. MossChen ChenSamantha L. CyrillMichael F. CicconeMarygrace C. TrousdellShih-Ting YangWesley D. FreyJohn E. WilkinsonCamila O. dos SantosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mary J. Feigman Matthew A. Moss Chen Chen Samantha L. Cyrill Michael F. Ciccone Marygrace C. Trousdell Shih-Ting Yang Wesley D. Frey John E. Wilkinson Camila O. dos Santos Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions
description	Mammary epithelial cells are epigenetically modified during pregnancy, these changes can influence the pre-disposition to cancer. Here, the authors examine the epigenetic landscape of mammary epithelial cells pre and post pregnancy and identify changes to the epigenetic landscape, which can protect mice from Myc induced cancer.
format	article
author	Mary J. Feigman Matthew A. Moss Chen Chen Samantha L. Cyrill Michael F. Ciccone Marygrace C. Trousdell Shih-Ting Yang Wesley D. Frey John E. Wilkinson Camila O. dos Santos
author_facet	Mary J. Feigman Matthew A. Moss Chen Chen Samantha L. Cyrill Michael F. Ciccone Marygrace C. Trousdell Shih-Ting Yang Wesley D. Frey John E. Wilkinson Camila O. dos Santos
author_sort	Mary J. Feigman
title	Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions
title_short	Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions
title_full	Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions
title_fullStr	Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions
title_full_unstemmed	Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions
title_sort	pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/be6daa3b32964ca8879edb8c33935d36
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Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions

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