Genome scale patterns of supercoiling in a bacterial chromosome

Bacterial DNA primarily exists in a negatively supercoiled or under-wound state. Here, by mapping the supercoiling state, the authors show that there is a gradient of supercoiling across the bacterial chromosome with the terminus being more negatively supercoiled than the origin.

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Detalles Bibliográficos
Autores principales: Avantika Lal, Amlanjyoti Dhar, Andrei Trostel, Fedor Kouzine, Aswin S. N. Seshasayee, Sankar Adhya
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/be7611785c574ff2bbac48aeae9ad064
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Sumario:Bacterial DNA primarily exists in a negatively supercoiled or under-wound state. Here, by mapping the supercoiling state, the authors show that there is a gradient of supercoiling across the bacterial chromosome with the terminus being more negatively supercoiled than the origin.