Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.

Ultra-high field MRI at 7 T can produce much better visualization of sub-cortical structures compared to lower field, which can greatly help target verification as well as overall treatment monitoring for patients with deep brain stimulation (DBS) implants. However, use of 7 T MRI for such patients...

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Autores principales:	Bhumi Bhusal, Jason Stockmann, Bastien Guerin, Azma Mareyam, John Kirsch, Lawrence L Wald, Mark J Nolt, Joshua Rosenow, Roberto Lopez-Rosado, Behzad Elahi, Laleh Golestanirad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be7d81ee9c3d4fae970478e0143a2e00
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spelling	oai:doaj.org-article:be7d81ee9c3d4fae970478e0143a2e002021-12-02T20:14:47ZSafety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.1932-620310.1371/journal.pone.0257077https://doaj.org/article/be7d81ee9c3d4fae970478e0143a2e002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257077https://doaj.org/toc/1932-6203Ultra-high field MRI at 7 T can produce much better visualization of sub-cortical structures compared to lower field, which can greatly help target verification as well as overall treatment monitoring for patients with deep brain stimulation (DBS) implants. However, use of 7 T MRI for such patients is currently contra-indicated by guidelines from the device manufacturers due to the safety issues. The aim of this study was to provide an assessment of safety and image quality of ultra-high field magnetic resonance imaging at 7 T in patients with deep brain stimulation implants. We performed experiments with both lead-only and complete DBS systems implanted in anthropomorphic phantoms. RF heating was measured for 43 unique patient-derived device configurations. Magnetic force measurements were performed according to ASTM F2052 test method, and device integrity was assessed before and after experiments. Finally, we assessed electrode artifact in a cadaveric brain implanted with an isolated DBS lead. RF heating remained below 2°C, similar to a fever, with the 95% confidence interval between 0.38°C-0.52°C. Magnetic forces were well below forces imposed by gravity, and thus not a source of concern. No device malfunctioning was observed due to interference from MRI fields. Electrode artifact was most noticeable on MPRAGE and T2*GRE sequences, while it was minimized on T2-TSE images. Our work provides the safety assessment of ultra-high field MRI at 7 T in patients with DBS implants. Our results suggest that 7 T MRI may be performed safely in patients with DBS implants for specific implant models and MRI hardware.Bhumi BhusalJason StockmannBastien GuerinAzma MareyamJohn KirschLawrence L WaldMark J NoltJoshua RosenowRoberto Lopez-RosadoBehzad ElahiLaleh GolestaniradPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bhumi Bhusal Jason Stockmann Bastien Guerin Azma Mareyam John Kirsch Lawrence L Wald Mark J Nolt Joshua Rosenow Roberto Lopez-Rosado Behzad Elahi Laleh Golestanirad Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.
description	Ultra-high field MRI at 7 T can produce much better visualization of sub-cortical structures compared to lower field, which can greatly help target verification as well as overall treatment monitoring for patients with deep brain stimulation (DBS) implants. However, use of 7 T MRI for such patients is currently contra-indicated by guidelines from the device manufacturers due to the safety issues. The aim of this study was to provide an assessment of safety and image quality of ultra-high field magnetic resonance imaging at 7 T in patients with deep brain stimulation implants. We performed experiments with both lead-only and complete DBS systems implanted in anthropomorphic phantoms. RF heating was measured for 43 unique patient-derived device configurations. Magnetic force measurements were performed according to ASTM F2052 test method, and device integrity was assessed before and after experiments. Finally, we assessed electrode artifact in a cadaveric brain implanted with an isolated DBS lead. RF heating remained below 2°C, similar to a fever, with the 95% confidence interval between 0.38°C-0.52°C. Magnetic forces were well below forces imposed by gravity, and thus not a source of concern. No device malfunctioning was observed due to interference from MRI fields. Electrode artifact was most noticeable on MPRAGE and T2*GRE sequences, while it was minimized on T2-TSE images. Our work provides the safety assessment of ultra-high field MRI at 7 T in patients with DBS implants. Our results suggest that 7 T MRI may be performed safely in patients with DBS implants for specific implant models and MRI hardware.
format	article
author	Bhumi Bhusal Jason Stockmann Bastien Guerin Azma Mareyam John Kirsch Lawrence L Wald Mark J Nolt Joshua Rosenow Roberto Lopez-Rosado Behzad Elahi Laleh Golestanirad
author_facet	Bhumi Bhusal Jason Stockmann Bastien Guerin Azma Mareyam John Kirsch Lawrence L Wald Mark J Nolt Joshua Rosenow Roberto Lopez-Rosado Behzad Elahi Laleh Golestanirad
author_sort	Bhumi Bhusal
title	Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.
title_short	Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.
title_full	Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.
title_fullStr	Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.
title_full_unstemmed	Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.
title_sort	safety and image quality at 7t mri for deep brain stimulation systems: ex vivo study with lead-only and full-systems.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/be7d81ee9c3d4fae970478e0143a2e00
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Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems.

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