The aging process and potential interventions to extend life expectancy

Matteo Tosato1, Valentina Zamboni1, Alessandro Ferrini1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, F...

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Autores principales:	Matteo Tosato, Valentina Zamboni, Alessandro Ferrini, Matteo Cesari
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/be7e031fbf834da5a3a4260f3c0f46de
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spelling	oai:doaj.org-article:be7e031fbf834da5a3a4260f3c0f46de2021-12-02T04:41:57ZThe aging process and potential interventions to extend life expectancy1178-1998https://doaj.org/article/be7e031fbf834da5a3a4260f3c0f46de2007-10-01T00:00:00Zhttps://www.dovepress.com/the-aging-process-and-potential-interventions-to-extend-life-expectanc-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Matteo Tosato1, Valentina Zamboni1, Alessandro Ferrini1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USAAbstract: Aging is commonly defined as the accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that are responsible for the increased risk of disease and death. The major theories of aging are all specific of a particular cause of aging, providing useful and important insights for the understanding of age-related physiological changes. However, a global view of them is needed when debating of a process which is still obscure in some of its aspects. In this context, the search for a single cause of aging has recently been replaced by the view of aging as an extremely complex, multifactorial process. Therefore, the different theories of aging should not be considered as mutually exclusive, but complementary of others in the explanation of some or all the features of the normal aging process. To date, no convincing evidence showing the administration of existing “anti-aging” remedies can slow aging or increase longevity in humans is available. Nevertheless, several studies on animal models have shown that aging rates and life expectancy can be modified. The present review provides an overlook of the most commonly accepted theories of aging, providing current evidence of those interventions aimed at modifying the aging process.Keywords: Aging, anti-aging medicine, caloric restriction, oxidative damage, inflammation, physical exerciseMatteo TosatoValentina ZamboniAlessandro FerriniMatteo CesariDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 401-412 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Matteo Tosato Valentina Zamboni Alessandro Ferrini Matteo Cesari The aging process and potential interventions to extend life expectancy
description	Matteo Tosato1, Valentina Zamboni1, Alessandro Ferrini1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USAAbstract: Aging is commonly defined as the accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that are responsible for the increased risk of disease and death. The major theories of aging are all specific of a particular cause of aging, providing useful and important insights for the understanding of age-related physiological changes. However, a global view of them is needed when debating of a process which is still obscure in some of its aspects. In this context, the search for a single cause of aging has recently been replaced by the view of aging as an extremely complex, multifactorial process. Therefore, the different theories of aging should not be considered as mutually exclusive, but complementary of others in the explanation of some or all the features of the normal aging process. To date, no convincing evidence showing the administration of existing “anti-aging” remedies can slow aging or increase longevity in humans is available. Nevertheless, several studies on animal models have shown that aging rates and life expectancy can be modified. The present review provides an overlook of the most commonly accepted theories of aging, providing current evidence of those interventions aimed at modifying the aging process.Keywords: Aging, anti-aging medicine, caloric restriction, oxidative damage, inflammation, physical exercise
format	article
author	Matteo Tosato Valentina Zamboni Alessandro Ferrini Matteo Cesari
author_facet	Matteo Tosato Valentina Zamboni Alessandro Ferrini Matteo Cesari
author_sort	Matteo Tosato
title	The aging process and potential interventions to extend life expectancy
title_short	The aging process and potential interventions to extend life expectancy
title_full	The aging process and potential interventions to extend life expectancy
title_fullStr	The aging process and potential interventions to extend life expectancy
title_full_unstemmed	The aging process and potential interventions to extend life expectancy
title_sort	aging process and potential interventions to extend life expectancy
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/be7e031fbf834da5a3a4260f3c0f46de
work_keys_str_mv	AT matteotosato theagingprocessandpotentialinterventionstoextendlifeexpectancy AT valentinazamboni theagingprocessandpotentialinterventionstoextendlifeexpectancy AT alessandroferrini theagingprocessandpotentialinterventionstoextendlifeexpectancy AT matteocesari theagingprocessandpotentialinterventionstoextendlifeexpectancy AT matteotosato agingprocessandpotentialinterventionstoextendlifeexpectancy AT valentinazamboni agingprocessandpotentialinterventionstoextendlifeexpectancy AT alessandroferrini agingprocessandpotentialinterventionstoextendlifeexpectancy AT matteocesari agingprocessandpotentialinterventionstoextendlifeexpectancy
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The aging process and potential interventions to extend life expectancy

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