Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report

Gaia Pellitteri,1,2 Pierluigi Dolso,1 Mariarosaria Valente,1,2 Gian Luigi Gigli1– 3 1Clinical Neurology Unit, Department of Neurosciences, Udine University Hospital, Udine, Italy; 2Department of Medicine (DAME), University of Udine, Udine, Italy; 3Department of Mathematics, Informatics and...

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Autores principales:	Pellitteri G, Dolso P, Valente M, Gigli GL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nt1 cataplexy sexual dysfunction narcolepsy treatment. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/be7edb9333544c62b7abe7a1a33f098b
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spelling	oai:doaj.org-article:be7edb9333544c62b7abe7a1a33f098b2021-12-02T10:40:53ZOrgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report1179-1608https://doaj.org/article/be7edb9333544c62b7abe7a1a33f098b2020-12-01T00:00:00Zhttps://www.dovepress.com/orgasmolepsy-in-narcolepsy-type-1-responsive-to-pitolisant-a-case-repo-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Gaia Pellitteri,1,2 Pierluigi Dolso,1 Mariarosaria Valente,1,2 Gian Luigi Gigli1– 3 1Clinical Neurology Unit, Department of Neurosciences, Udine University Hospital, Udine, Italy; 2Department of Medicine (DAME), University of Udine, Udine, Italy; 3Department of Mathematics, Informatics and Physics (DMIF), University of Udine, Udine, ItalyCorrespondence: Gaia PellitteriClinical Neurology Unit, Department of Neurosciences, Udine University Hospital, P.le S. Maria Della Misericordia 15, Udine 33100, ItalyTel +39 3343351338Fax +39 0432 552287Email pellitteri.gaia@gmail.comAbstract: We describe a case of a young male patient with narcolepsy type 1 (NT1), who developed generalized cataplexy attacks during sexual intercourses, on which we have obtained a satisfactory control with pitolisant. Orgasmolepsy is an uncommon feature of NT1 that has been poorly described in the literature. The prevalence of this condition is unclear, as it is reasonably underreported by patients for embarrassment and not well investigated by physicians. Pitolisant is a novel treatment for narcolepsy, effective on excessive daytime sleepiness and cataplexy by modulating the histaminergic system. Real-world data collection on pitolisant efficacy and safety is still ongoing. However, pitolisant effectiveness on orgasmolepsy in NT1 has no precedent in the literature. Orgasmolepsy and other sexual disturbances should be actively searched in narcoleptic patients and, if present, may guide clinicians to prefer pitolisant or sodium oxybate, avoiding antidepressants for their possible sexual side effects.Keywords: NT1, cataplexy, sexual dysfunction, narcolepsy treatmentPellitteri GDolso PValente MGigli GLDove Medical Pressarticlent1cataplexysexual dysfunctionnarcolepsy treatment.PsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 1237-1240 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nt1 cataplexy sexual dysfunction narcolepsy treatment. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	nt1 cataplexy sexual dysfunction narcolepsy treatment. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Pellitteri G Dolso P Valente M Gigli GL Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report
description	Gaia Pellitteri,1,2 Pierluigi Dolso,1 Mariarosaria Valente,1,2 Gian Luigi Gigli1– 3 1Clinical Neurology Unit, Department of Neurosciences, Udine University Hospital, Udine, Italy; 2Department of Medicine (DAME), University of Udine, Udine, Italy; 3Department of Mathematics, Informatics and Physics (DMIF), University of Udine, Udine, ItalyCorrespondence: Gaia PellitteriClinical Neurology Unit, Department of Neurosciences, Udine University Hospital, P.le S. Maria Della Misericordia 15, Udine 33100, ItalyTel +39 3343351338Fax +39 0432 552287Email pellitteri.gaia@gmail.comAbstract: We describe a case of a young male patient with narcolepsy type 1 (NT1), who developed generalized cataplexy attacks during sexual intercourses, on which we have obtained a satisfactory control with pitolisant. Orgasmolepsy is an uncommon feature of NT1 that has been poorly described in the literature. The prevalence of this condition is unclear, as it is reasonably underreported by patients for embarrassment and not well investigated by physicians. Pitolisant is a novel treatment for narcolepsy, effective on excessive daytime sleepiness and cataplexy by modulating the histaminergic system. Real-world data collection on pitolisant efficacy and safety is still ongoing. However, pitolisant effectiveness on orgasmolepsy in NT1 has no precedent in the literature. Orgasmolepsy and other sexual disturbances should be actively searched in narcoleptic patients and, if present, may guide clinicians to prefer pitolisant or sodium oxybate, avoiding antidepressants for their possible sexual side effects.Keywords: NT1, cataplexy, sexual dysfunction, narcolepsy treatment
format	article
author	Pellitteri G Dolso P Valente M Gigli GL
author_facet	Pellitteri G Dolso P Valente M Gigli GL
author_sort	Pellitteri G
title	Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report
title_short	Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report
title_full	Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report
title_fullStr	Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report
title_full_unstemmed	Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report
title_sort	orgasmolepsy in narcolepsy type 1 responsive to pitolisant: a case report
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/be7edb9333544c62b7abe7a1a33f098b
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Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report

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