YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer

Histone modification recognition is an important mechanism for gene expression regulation in cancer. Here, the authors identify YEATS2 as a histone H3K27ac reader, regulating a transcriptional program essential for tumorigenesis in human non-small cell lung cancer.

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Autores principales: Wenyi Mi, Haipeng Guan, Jie Lyu, Dan Zhao, Yuanxin Xi, Shiming Jiang, Forest H. Andrews, Xiaolu Wang, Mihai Gagea, Hong Wen, Laszlo Tora, Sharon Y. R. Dent, Tatiana G. Kutateladze, Wei Li, Haitao Li, Xiaobing Shi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/be7fccc0c928460dac1868ae040b124c
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spelling oai:doaj.org-article:be7fccc0c928460dac1868ae040b124c2021-12-02T15:37:04ZYEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer10.1038/s41467-017-01173-42041-1723https://doaj.org/article/be7fccc0c928460dac1868ae040b124c2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01173-4https://doaj.org/toc/2041-1723Histone modification recognition is an important mechanism for gene expression regulation in cancer. Here, the authors identify YEATS2 as a histone H3K27ac reader, regulating a transcriptional program essential for tumorigenesis in human non-small cell lung cancer.Wenyi MiHaipeng GuanJie LyuDan ZhaoYuanxin XiShiming JiangForest H. AndrewsXiaolu WangMihai GageaHong WenLaszlo ToraSharon Y. R. DentTatiana G. KutateladzeWei LiHaitao LiXiaobing ShiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wenyi Mi
Haipeng Guan
Jie Lyu
Dan Zhao
Yuanxin Xi
Shiming Jiang
Forest H. Andrews
Xiaolu Wang
Mihai Gagea
Hong Wen
Laszlo Tora
Sharon Y. R. Dent
Tatiana G. Kutateladze
Wei Li
Haitao Li
Xiaobing Shi
YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
description Histone modification recognition is an important mechanism for gene expression regulation in cancer. Here, the authors identify YEATS2 as a histone H3K27ac reader, regulating a transcriptional program essential for tumorigenesis in human non-small cell lung cancer.
format article
author Wenyi Mi
Haipeng Guan
Jie Lyu
Dan Zhao
Yuanxin Xi
Shiming Jiang
Forest H. Andrews
Xiaolu Wang
Mihai Gagea
Hong Wen
Laszlo Tora
Sharon Y. R. Dent
Tatiana G. Kutateladze
Wei Li
Haitao Li
Xiaobing Shi
author_facet Wenyi Mi
Haipeng Guan
Jie Lyu
Dan Zhao
Yuanxin Xi
Shiming Jiang
Forest H. Andrews
Xiaolu Wang
Mihai Gagea
Hong Wen
Laszlo Tora
Sharon Y. R. Dent
Tatiana G. Kutateladze
Wei Li
Haitao Li
Xiaobing Shi
author_sort Wenyi Mi
title YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
title_short YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
title_full YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
title_fullStr YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
title_full_unstemmed YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer
title_sort yeats2 links histone acetylation to tumorigenesis of non-small cell lung cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/be7fccc0c928460dac1868ae040b124c
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