Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution

Cancer derived exosomes are reported to promote metastatic dissemination. Here the authors show that cytokines in the tumor microenvironment bind to exosomes via glycosaminoglycan side chains of proteoglycans, and these exosomes are preferentially taken up by specific cell lineages and organs to pro...

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Autores principales:	Luize G. Lima, Sunyoung Ham, Hyunku Shin, Edna P. Z. Chai, Erica S. H. Lek, Richard J. Lobb, Alexandra F. Müller, Suresh Mathivanan, Belinda Yeo, Yeonho Choi, Belinda S. Parker, Andreas Möller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be811a215f504d5cbb62cdb4db51b81d
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spelling	oai:doaj.org-article:be811a215f504d5cbb62cdb4db51b81d2021-12-02T18:06:25ZTumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution10.1038/s41467-021-23946-82041-1723https://doaj.org/article/be811a215f504d5cbb62cdb4db51b81d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23946-8https://doaj.org/toc/2041-1723Cancer derived exosomes are reported to promote metastatic dissemination. Here the authors show that cytokines in the tumor microenvironment bind to exosomes via glycosaminoglycan side chains of proteoglycans, and these exosomes are preferentially taken up by specific cell lineages and organs to promote metastasis.Luize G. LimaSunyoung HamHyunku ShinEdna P. Z. ChaiErica S. H. LekRichard J. LobbAlexandra F. MüllerSuresh MathivananBelinda YeoYeonho ChoiBelinda S. ParkerAndreas MöllerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luize G. Lima Sunyoung Ham Hyunku Shin Edna P. Z. Chai Erica S. H. Lek Richard J. Lobb Alexandra F. Müller Suresh Mathivanan Belinda Yeo Yeonho Choi Belinda S. Parker Andreas Möller Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
description	Cancer derived exosomes are reported to promote metastatic dissemination. Here the authors show that cytokines in the tumor microenvironment bind to exosomes via glycosaminoglycan side chains of proteoglycans, and these exosomes are preferentially taken up by specific cell lineages and organs to promote metastasis.
format	article
author	Luize G. Lima Sunyoung Ham Hyunku Shin Edna P. Z. Chai Erica S. H. Lek Richard J. Lobb Alexandra F. Müller Suresh Mathivanan Belinda Yeo Yeonho Choi Belinda S. Parker Andreas Möller
author_facet	Luize G. Lima Sunyoung Ham Hyunku Shin Edna P. Z. Chai Erica S. H. Lek Richard J. Lobb Alexandra F. Müller Suresh Mathivanan Belinda Yeo Yeonho Choi Belinda S. Parker Andreas Möller
author_sort	Luize G. Lima
title	Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
title_short	Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
title_full	Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
title_fullStr	Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
title_full_unstemmed	Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
title_sort	tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/be811a215f504d5cbb62cdb4db51b81d
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Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution

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