Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus

Aim. To elucidate the role of diabetic nephropathy in pathogenesis of myo-cardial lesions in children with type 1 diabetes mellitus from the results of dopplerography of intrarenal vessels. Materials and methods. The study involved 39 children with DM1 (mean age 12,5?2,6) divided into 2 groups. Grou...

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Autores principales:	Larisa Vasil'evna Kazakova, Elena Fedorovna Lukushkina, Leonid Grigor'evich Strongin, Elena Alexandrovna Azova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	diabetic nephropathy, type 1 diabetes mellitus of children, dopplerography, cardiopathy Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/be81ed63e8464309a26fd23c20c10143
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spelling	oai:doaj.org-article:be81ed63e8464309a26fd23c20c101432021-11-14T09:00:14ZDiabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus2072-03512072-037810.14341/2072-0351-5451https://doaj.org/article/be81ed63e8464309a26fd23c20c101432009-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5451https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To elucidate the role of diabetic nephropathy in pathogenesis of myo-cardial lesions in children with type 1 diabetes mellitus from the results of dopplerography of intrarenal vessels. Materials and methods. The study involved 39 children with DM1 (mean age 12,5?2,6) divided into 2 groups. Group 1 included 12 patients with subclinical diabetic lesions in the kidneys (hyperfiltration), group 2 and 3 comprised 21 and 6 patients with diabetic neph-ropathy (microalbuminuria 30?300 mg/day or proteinuria respectively). All patients under-went standard examination to evaluate cardiovascular and vegetative nervous function. Analysis of spectrograms obtained by dopplerography of intrarenal vessels included main renal artery (MRA), segmental (SA), interlobe (ILA), arch (AA), and interlobular (ILbA) arteries. Results. The study groups were not significantly different in terms of MRA, SA, AA, and ILA hemodynamics but, unlike healthy controls, showed a nonlinear decreasing gradient in vascular resistance from MRA toward peripheral vessels especially ILA and AA. Left ven-tricular hypertrophy with disturbed diastolic performance documented in 64% of the patients correlated with microalbuminuria (r=0,56, pLarisa Vasil'evna KazakovaElena Fedorovna LukushkinaLeonid Grigor'evich StronginElena Alexandrovna AzovaEndocrinology Research Centrearticlediabetic nephropathy, type 1 diabetes mellitus of children, dopplerography, cardiopathyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 3, Pp 43-48 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetic nephropathy, type 1 diabetes mellitus of children, dopplerography, cardiopathy Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetic nephropathy, type 1 diabetes mellitus of children, dopplerography, cardiopathy Nutritional diseases. Deficiency diseases RC620-627 Larisa Vasil'evna Kazakova Elena Fedorovna Lukushkina Leonid Grigor'evich Strongin Elena Alexandrovna Azova Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus
description	Aim. To elucidate the role of diabetic nephropathy in pathogenesis of myo-cardial lesions in children with type 1 diabetes mellitus from the results of dopplerography of intrarenal vessels. Materials and methods. The study involved 39 children with DM1 (mean age 12,5?2,6) divided into 2 groups. Group 1 included 12 patients with subclinical diabetic lesions in the kidneys (hyperfiltration), group 2 and 3 comprised 21 and 6 patients with diabetic neph-ropathy (microalbuminuria 30?300 mg/day or proteinuria respectively). All patients under-went standard examination to evaluate cardiovascular and vegetative nervous function. Analysis of spectrograms obtained by dopplerography of intrarenal vessels included main renal artery (MRA), segmental (SA), interlobe (ILA), arch (AA), and interlobular (ILbA) arteries. Results. The study groups were not significantly different in terms of MRA, SA, AA, and ILA hemodynamics but, unlike healthy controls, showed a nonlinear decreasing gradient in vascular resistance from MRA toward peripheral vessels especially ILA and AA. Left ven-tricular hypertrophy with disturbed diastolic performance documented in 64% of the patients correlated with microalbuminuria (r=0,56, p
format	article
author	Larisa Vasil'evna Kazakova Elena Fedorovna Lukushkina Leonid Grigor'evich Strongin Elena Alexandrovna Azova
author_facet	Larisa Vasil'evna Kazakova Elena Fedorovna Lukushkina Leonid Grigor'evich Strongin Elena Alexandrovna Azova
author_sort	Larisa Vasil'evna Kazakova
title	Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus
title_short	Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus
title_full	Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus
title_fullStr	Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus
title_full_unstemmed	Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus
title_sort	diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/be81ed63e8464309a26fd23c20c10143
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Diabetic nephropathy and myocardial lesions in children with type 1 diabetes mellitus

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