The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses
The tumor suppressor p53 is activated upon multiple cellular stresses, including DNA damage, oncogene activation, ribosomal stress, and hypoxia, to induce cell cycle arrest, apoptosis, and senescence. Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase,...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:be8243f9ca5a43928a5ffb34f1562e532021-11-18T16:44:22ZThe Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses2296-634X10.3389/fcell.2021.775507https://doaj.org/article/be8243f9ca5a43928a5ffb34f1562e532021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.775507/fullhttps://doaj.org/toc/2296-634XThe tumor suppressor p53 is activated upon multiple cellular stresses, including DNA damage, oncogene activation, ribosomal stress, and hypoxia, to induce cell cycle arrest, apoptosis, and senescence. Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, serves as a central regulator of cell growth, proliferation, and survival by coordinating nutrients, energy, growth factors, and oxygen levels. p53 dysfunction and mTOR pathway hyperactivation are hallmarks of human cancer. The balance between response to stresses or commitment to cell proliferation and survival is governed by various regulatory loops between the p53 and mTOR pathways. In this review, we first briefly introduce the tumor suppressor p53 and then describe the upstream regulators and downstream effectors of the mTOR pathway. Next, we discuss the role of p53 in regulating the mTOR pathway through its transcriptional and non-transcriptional effects. We further describe the complicated role of the mTOR pathway in modulating p53 activity. Finally, we discuss the current knowledge and future perspectives on the coordinated regulation of the p53 and mTOR pathways.Danrui CuiDanrui CuiDanrui CuiRuirui QuRuirui QuRuirui QuDian LiuDian LiuDian LiuXiufang XiongXiufang XiongTingbo LiangTingbo LiangTingbo LiangYongchao ZhaoYongchao ZhaoYongchao ZhaoYongchao ZhaoFrontiers Media S.A.articlep53mTORtranscriptionmiRNAtumorigenesisMDM2Biology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
p53 mTOR transcription miRNA tumorigenesis MDM2 Biology (General) QH301-705.5 |
| spellingShingle |
p53 mTOR transcription miRNA tumorigenesis MDM2 Biology (General) QH301-705.5 Danrui Cui Danrui Cui Danrui Cui Ruirui Qu Ruirui Qu Ruirui Qu Dian Liu Dian Liu Dian Liu Xiufang Xiong Xiufang Xiong Tingbo Liang Tingbo Liang Tingbo Liang Yongchao Zhao Yongchao Zhao Yongchao Zhao Yongchao Zhao The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses |
| description |
The tumor suppressor p53 is activated upon multiple cellular stresses, including DNA damage, oncogene activation, ribosomal stress, and hypoxia, to induce cell cycle arrest, apoptosis, and senescence. Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, serves as a central regulator of cell growth, proliferation, and survival by coordinating nutrients, energy, growth factors, and oxygen levels. p53 dysfunction and mTOR pathway hyperactivation are hallmarks of human cancer. The balance between response to stresses or commitment to cell proliferation and survival is governed by various regulatory loops between the p53 and mTOR pathways. In this review, we first briefly introduce the tumor suppressor p53 and then describe the upstream regulators and downstream effectors of the mTOR pathway. Next, we discuss the role of p53 in regulating the mTOR pathway through its transcriptional and non-transcriptional effects. We further describe the complicated role of the mTOR pathway in modulating p53 activity. Finally, we discuss the current knowledge and future perspectives on the coordinated regulation of the p53 and mTOR pathways. |
| format |
article |
| author |
Danrui Cui Danrui Cui Danrui Cui Ruirui Qu Ruirui Qu Ruirui Qu Dian Liu Dian Liu Dian Liu Xiufang Xiong Xiufang Xiong Tingbo Liang Tingbo Liang Tingbo Liang Yongchao Zhao Yongchao Zhao Yongchao Zhao Yongchao Zhao |
| author_facet |
Danrui Cui Danrui Cui Danrui Cui Ruirui Qu Ruirui Qu Ruirui Qu Dian Liu Dian Liu Dian Liu Xiufang Xiong Xiufang Xiong Tingbo Liang Tingbo Liang Tingbo Liang Yongchao Zhao Yongchao Zhao Yongchao Zhao Yongchao Zhao |
| author_sort |
Danrui Cui |
| title |
The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses |
| title_short |
The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses |
| title_full |
The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses |
| title_fullStr |
The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses |
| title_full_unstemmed |
The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses |
| title_sort |
cross talk between p53 and mtor pathways in response to physiological and genotoxic stresses |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/be8243f9ca5a43928a5ffb34f1562e53 |
| work_keys_str_mv |
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