Dampening of neurotransmitter action: molecular similarity within the melatonin structure

Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides. Melatonin’s interaction with other G-protein regulated receptors, including those of serotonin, is unclear. This stu...

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Autor principal:	Williams Wynford R.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	melatonin gpcr ion channels molecular similarity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/be825141ee5349849472dec7dc044d0b
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spelling	oai:doaj.org-article:be825141ee5349849472dec7dc044d0b2021-12-02T16:40:25ZDampening of neurotransmitter action: molecular similarity within the melatonin structure1336-032910.2478/enr-2018-0025https://doaj.org/article/be825141ee5349849472dec7dc044d0b2018-10-01T00:00:00Zhttps://doi.org/10.2478/enr-2018-0025https://doaj.org/toc/1336-0329Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides. Melatonin’s interaction with other G-protein regulated receptors, including those of serotonin, is unclear. This study explores the potential for the interaction of melatonin with nucleotide and receptor ligand structures. Methods. The study uses a computational program to investigate relative molecular similarity by the comparative superimposition and quantitative fitting of molecular structures to adenine and guanine nucleotide templates. Results. A minimum energy melatonin conformer replicates the nucleotide fits of ligand structures that regulate Gαi and Gαq proteins via serotonin, dopamine, opioid, α-adrenoceptor, and muscarinic receptor classes. The same conformer also replicates the nucleotide fits of ligand structures regulating K+ and Ca2+ ion channels. The acyl-methoxy distance within the melatonin conformer matches a carbonyl-hydroxyl distance in guanine nucleotide. Conclusion. Molecular similarity within the melatonin and ligand structures relates to the established effects of melatonin on cell receptors regulated by purine nucleotides in cell signal transduction processes. Pharmacologic receptor promiscuity may contribute to the widespread effects of melatonin.Williams Wynford R.Sciendoarticlemelatoningpcrion channelsmolecular similarityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 52, Iss 4, Pp 199-207 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	melatonin gpcr ion channels molecular similarity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	melatonin gpcr ion channels molecular similarity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Williams Wynford R. Dampening of neurotransmitter action: molecular similarity within the melatonin structure
description	Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides. Melatonin’s interaction with other G-protein regulated receptors, including those of serotonin, is unclear. This study explores the potential for the interaction of melatonin with nucleotide and receptor ligand structures. Methods. The study uses a computational program to investigate relative molecular similarity by the comparative superimposition and quantitative fitting of molecular structures to adenine and guanine nucleotide templates. Results. A minimum energy melatonin conformer replicates the nucleotide fits of ligand structures that regulate Gαi and Gαq proteins via serotonin, dopamine, opioid, α-adrenoceptor, and muscarinic receptor classes. The same conformer also replicates the nucleotide fits of ligand structures regulating K+ and Ca2+ ion channels. The acyl-methoxy distance within the melatonin conformer matches a carbonyl-hydroxyl distance in guanine nucleotide. Conclusion. Molecular similarity within the melatonin and ligand structures relates to the established effects of melatonin on cell receptors regulated by purine nucleotides in cell signal transduction processes. Pharmacologic receptor promiscuity may contribute to the widespread effects of melatonin.
format	article
author	Williams Wynford R.
author_facet	Williams Wynford R.
author_sort	Williams Wynford R.
title	Dampening of neurotransmitter action: molecular similarity within the melatonin structure
title_short	Dampening of neurotransmitter action: molecular similarity within the melatonin structure
title_full	Dampening of neurotransmitter action: molecular similarity within the melatonin structure
title_fullStr	Dampening of neurotransmitter action: molecular similarity within the melatonin structure
title_full_unstemmed	Dampening of neurotransmitter action: molecular similarity within the melatonin structure
title_sort	dampening of neurotransmitter action: molecular similarity within the melatonin structure
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/be825141ee5349849472dec7dc044d0b
work_keys_str_mv	AT williamswynfordr dampeningofneurotransmitteractionmolecularsimilaritywithinthemelatoninstructure
_version_	1718383598474625024

Dampening of neurotransmitter action: molecular similarity within the melatonin structure

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