Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity

Songwei Yang1 1, Min Yu2 2 1Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2Department of General Surgery, Xinqiao Hospital, Third Military Medical Universi...

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Autores principales:	Yang S, Yu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	goblet cell intestinal tract intestinal barrier mucosal immunity cytokine mucin2 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/be86aeed92374404ab6025a4bb9454c7
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spelling	oai:doaj.org-article:be86aeed92374404ab6025a4bb9454c72021-12-02T16:11:44ZRole of Goblet Cells in Intestinal Barrier and Mucosal Immunity1178-7031https://doaj.org/article/be86aeed92374404ab6025a4bb9454c72021-07-01T00:00:00Zhttps://www.dovepress.com/role-of-goblet-cells-in-intestinal-barrier-and-mucosal-immunity-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Songwei Yang1 1, Min Yu2 2 1Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People’s Republic of ChinaCorrespondence: Songwei Yang; Min Yu Tel/Fax +8623-653-10296; +8623-687-55705Email yangsongwei01@126.com; yumimianbao@163.comAbstract: Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet cells and mucus has changed, with current evidence suggesting that they are not passive but play a positive role in maintaining intestinal tract immunity and mucosal homeostasis. Goblet cells could obtain luminal antigens, presenting them to the underlying antigen-presenting cells (APCs) that induces adaptive immune responses. Various immunomodulatory factors can promote the differentiation and maturation of goblet cells, and the secretion of mucin. The abnormal proliferation and differentiation of goblet cells, as well as the deficiency synthesis and secretion of mucins, result in intestinal mucosal barrier dysfunction. This review provides an extensive outline of the signaling pathways that regulate goblet cell proliferation and differentiation and control mucins synthesis and secretion to elucidate how altering these pathways affects goblet functionality. Furthermore, the interaction between mucins and goblet cells in intestinal mucosal immunology is described. Therefore, the contribution of goblet cells and mucus in promoting gut defense and homeostasis is illustrated, while clarifying the regulatory mechanisms involved may allow the development of new therapeutic strategies for intestinal disorders.Keywords: goblet cell, intestinal tract, intestinal barrier, mucosal immunity, cytokine, Mucin2Yang SYu MDove Medical Pressarticlegoblet cellintestinal tractintestinal barriermucosal immunitycytokinemucin2PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 3171-3183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	goblet cell intestinal tract intestinal barrier mucosal immunity cytokine mucin2 Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	goblet cell intestinal tract intestinal barrier mucosal immunity cytokine mucin2 Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Yang S Yu M Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
description	Songwei Yang1 1, Min Yu2 2 1Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People’s Republic of ChinaCorrespondence: Songwei Yang; Min Yu Tel/Fax +8623-653-10296; +8623-687-55705Email yangsongwei01@126.com; yumimianbao@163.comAbstract: Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet cells and mucus has changed, with current evidence suggesting that they are not passive but play a positive role in maintaining intestinal tract immunity and mucosal homeostasis. Goblet cells could obtain luminal antigens, presenting them to the underlying antigen-presenting cells (APCs) that induces adaptive immune responses. Various immunomodulatory factors can promote the differentiation and maturation of goblet cells, and the secretion of mucin. The abnormal proliferation and differentiation of goblet cells, as well as the deficiency synthesis and secretion of mucins, result in intestinal mucosal barrier dysfunction. This review provides an extensive outline of the signaling pathways that regulate goblet cell proliferation and differentiation and control mucins synthesis and secretion to elucidate how altering these pathways affects goblet functionality. Furthermore, the interaction between mucins and goblet cells in intestinal mucosal immunology is described. Therefore, the contribution of goblet cells and mucus in promoting gut defense and homeostasis is illustrated, while clarifying the regulatory mechanisms involved may allow the development of new therapeutic strategies for intestinal disorders.Keywords: goblet cell, intestinal tract, intestinal barrier, mucosal immunity, cytokine, Mucin2
format	article
author	Yang S Yu M
author_facet	Yang S Yu M
author_sort	Yang S
title	Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
title_short	Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
title_full	Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
title_fullStr	Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
title_full_unstemmed	Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
title_sort	role of goblet cells in intestinal barrier and mucosal immunity
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/be86aeed92374404ab6025a4bb9454c7
work_keys_str_mv	AT yangs roleofgobletcellsinintestinalbarrierandmucosalimmunity AT yum roleofgobletcellsinintestinalbarrierandmucosalimmunity
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Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity

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