Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment

Abstract In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoe...

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Autores principales:	Aaron Martínez-Higuera, César Rodríguez-Beas, Jesús Mauro Adolfo Villalobos-Noriega, Abraham Arizmendi-Grijalva, Carlos Ochoa-Sánchez, Eduardo Larios-Rodríguez, Juan Manuel Martínez-Soto, Ericka Rodríguez-León, Cristina Ibarra-Zazueta, Roberto Mora-Monroy, Hugo Alejandro Borbón-Nuñez, Alfonso García-Galaz, María del Carmen Candia-Plata, Luis Fernando López-Soto, Ramón Iñiguez-Palomares
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be8b6a0a451648129c5c199a4704cdb6
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spelling	oai:doaj.org-article:be8b6a0a451648129c5c199a4704cdb62021-12-02T15:00:51ZHydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment10.1038/s41598-021-90763-w2045-2322https://doaj.org/article/be8b6a0a451648129c5c199a4704cdb62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90763-whttps://doaj.org/toc/2045-2322Abstract In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV–Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.Aaron Martínez-HigueraCésar Rodríguez-BeasJesús Mauro Adolfo Villalobos-NoriegaAbraham Arizmendi-GrijalvaCarlos Ochoa-SánchezEduardo Larios-RodríguezJuan Manuel Martínez-SotoEricka Rodríguez-LeónCristina Ibarra-ZazuetaRoberto Mora-MonroyHugo Alejandro Borbón-NuñezAlfonso García-GalazMaría del Carmen Candia-PlataLuis Fernando López-SotoRamón Iñiguez-PalomaresNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aaron Martínez-Higuera César Rodríguez-Beas Jesús Mauro Adolfo Villalobos-Noriega Abraham Arizmendi-Grijalva Carlos Ochoa-Sánchez Eduardo Larios-Rodríguez Juan Manuel Martínez-Soto Ericka Rodríguez-León Cristina Ibarra-Zazueta Roberto Mora-Monroy Hugo Alejandro Borbón-Nuñez Alfonso García-Galaz María del Carmen Candia-Plata Luis Fernando López-Soto Ramón Iñiguez-Palomares Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment
description	Abstract In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV–Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.
format	article
author	Aaron Martínez-Higuera César Rodríguez-Beas Jesús Mauro Adolfo Villalobos-Noriega Abraham Arizmendi-Grijalva Carlos Ochoa-Sánchez Eduardo Larios-Rodríguez Juan Manuel Martínez-Soto Ericka Rodríguez-León Cristina Ibarra-Zazueta Roberto Mora-Monroy Hugo Alejandro Borbón-Nuñez Alfonso García-Galaz María del Carmen Candia-Plata Luis Fernando López-Soto Ramón Iñiguez-Palomares
author_facet	Aaron Martínez-Higuera César Rodríguez-Beas Jesús Mauro Adolfo Villalobos-Noriega Abraham Arizmendi-Grijalva Carlos Ochoa-Sánchez Eduardo Larios-Rodríguez Juan Manuel Martínez-Soto Ericka Rodríguez-León Cristina Ibarra-Zazueta Roberto Mora-Monroy Hugo Alejandro Borbón-Nuñez Alfonso García-Galaz María del Carmen Candia-Plata Luis Fernando López-Soto Ramón Iñiguez-Palomares
author_sort	Aaron Martínez-Higuera
title	Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment
title_short	Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment
title_full	Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment
title_fullStr	Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment
title_full_unstemmed	Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment
title_sort	hydrogel with silver nanoparticles synthesized by mimosa tenuiflora for second-degree burns treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/be8b6a0a451648129c5c199a4704cdb6
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Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment

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