Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2

Objectives: Monitoring the antibody responses to SARS-CoV-2 infection and its correlation to clinical spectrum of disease is critical in understanding the disease progression and protection against re-infection. We assessed the nucleocapsid (N) and receptor-binding-domain of spike (SRBD) protein spe...

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Autores principales:	Gururaj Rao Deshpande, Ojas Kaduskar, Ketki Deshpande, Vaishali Bhatt, Pragya Yadav, Yogesh Gurav, Varsha Potdar, Kirti Khutwad, Shankar Vidhate, Asha Salunke, Chetan Patil, Snehal Shingade, Kajal Jarande, Bipin Tilekar, Pavan Salvi, Sudhir Patsuthe, Varsha Dange, Sudeep Kumar, Shilpa Gurav, Sadhana Chate, Priya Abraham, Gajanan Sapkal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	SARS-CoV-2 nucleocapsid receptor binding domain neutralizing antibody response IgG antibody response 240 days Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/be8caf5e69754761acaad79a73d17f94
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spelling	oai:doaj.org-article:be8caf5e69754761acaad79a73d17f942021-11-30T04:14:14ZLongitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-21201-971210.1016/j.ijid.2021.09.024https://doaj.org/article/be8caf5e69754761acaad79a73d17f942021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007323https://doaj.org/toc/1201-9712Objectives: Monitoring the antibody responses to SARS-CoV-2 infection and its correlation to clinical spectrum of disease is critical in understanding the disease progression and protection against re-infection. We assessed the nucleocapsid (N) and receptor-binding-domain of spike (SRBD) protein specific IgG and neutralizing antibody (NAb) responses in COVID-19 patients up to 8 months and its correlation with diverse disease spectrum. Methods: During the first wave of the SARS-CoV-2 pandemic, from 284 COVID-19 patients, 608 samples were collected up to 8 months post infection. The patients were categorized as asymptomatic, symptomatic and severe. The N and SRBD IgG and NAb titers were evaluated and correlated with clinical data. Results: A steep increase in antigen specific antibody titers was observed till 40 days post onset of the disease (POD), followed by a partial decline till 240 days. Severe disease was associated with a stronger SRBD IgG response and higher NAb titers. The persistence of antibody response was observed in 76% against N, 80% against SRBD and 80% for NAbs of cases up to 8 months POD. Conclusion: RBD and N protein specific IgG persisted till 240 days POD which correlated with NAb response, irrespective of individual`s symptomatic status indicating overall robust protection against re-infection.Gururaj Rao DeshpandeOjas KaduskarKetki DeshpandeVaishali BhattPragya YadavYogesh GuravVarsha PotdarKirti KhutwadShankar VidhateAsha SalunkeChetan PatilSnehal ShingadeKajal JarandeBipin TilekarPavan SalviSudhir PatsutheVarsha DangeSudeep KumarShilpa GuravSadhana ChatePriya AbrahamGajanan SapkalElsevierarticleSARS-CoV-2nucleocapsidreceptor binding domainneutralizing antibody responseIgG antibody response240 daysInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 103-110 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 nucleocapsid receptor binding domain neutralizing antibody response IgG antibody response 240 days Infectious and parasitic diseases RC109-216
spellingShingle	SARS-CoV-2 nucleocapsid receptor binding domain neutralizing antibody response IgG antibody response 240 days Infectious and parasitic diseases RC109-216 Gururaj Rao Deshpande Ojas Kaduskar Ketki Deshpande Vaishali Bhatt Pragya Yadav Yogesh Gurav Varsha Potdar Kirti Khutwad Shankar Vidhate Asha Salunke Chetan Patil Snehal Shingade Kajal Jarande Bipin Tilekar Pavan Salvi Sudhir Patsuthe Varsha Dange Sudeep Kumar Shilpa Gurav Sadhana Chate Priya Abraham Gajanan Sapkal Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2
description	Objectives: Monitoring the antibody responses to SARS-CoV-2 infection and its correlation to clinical spectrum of disease is critical in understanding the disease progression and protection against re-infection. We assessed the nucleocapsid (N) and receptor-binding-domain of spike (SRBD) protein specific IgG and neutralizing antibody (NAb) responses in COVID-19 patients up to 8 months and its correlation with diverse disease spectrum. Methods: During the first wave of the SARS-CoV-2 pandemic, from 284 COVID-19 patients, 608 samples were collected up to 8 months post infection. The patients were categorized as asymptomatic, symptomatic and severe. The N and SRBD IgG and NAb titers were evaluated and correlated with clinical data. Results: A steep increase in antigen specific antibody titers was observed till 40 days post onset of the disease (POD), followed by a partial decline till 240 days. Severe disease was associated with a stronger SRBD IgG response and higher NAb titers. The persistence of antibody response was observed in 76% against N, 80% against SRBD and 80% for NAbs of cases up to 8 months POD. Conclusion: RBD and N protein specific IgG persisted till 240 days POD which correlated with NAb response, irrespective of individual`s symptomatic status indicating overall robust protection against re-infection.
format	article
author	Gururaj Rao Deshpande Ojas Kaduskar Ketki Deshpande Vaishali Bhatt Pragya Yadav Yogesh Gurav Varsha Potdar Kirti Khutwad Shankar Vidhate Asha Salunke Chetan Patil Snehal Shingade Kajal Jarande Bipin Tilekar Pavan Salvi Sudhir Patsuthe Varsha Dange Sudeep Kumar Shilpa Gurav Sadhana Chate Priya Abraham Gajanan Sapkal
author_facet	Gururaj Rao Deshpande Ojas Kaduskar Ketki Deshpande Vaishali Bhatt Pragya Yadav Yogesh Gurav Varsha Potdar Kirti Khutwad Shankar Vidhate Asha Salunke Chetan Patil Snehal Shingade Kajal Jarande Bipin Tilekar Pavan Salvi Sudhir Patsuthe Varsha Dange Sudeep Kumar Shilpa Gurav Sadhana Chate Priya Abraham Gajanan Sapkal
author_sort	Gururaj Rao Deshpande
title	Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2
title_short	Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2
title_full	Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2
title_fullStr	Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2
title_full_unstemmed	Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2
title_sort	longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against sars-cov-2
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/be8caf5e69754761acaad79a73d17f94
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Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2

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