THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE

Objective: The aim of this retrospective study is to evaluate fertility in the Philadelphia-negative MPN male patients and the effect of treatment received on male fertility and the outcome. Methodology: This is a single-center, mixed-design study (retrospective + phone interviews) conducted within...

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Autores principales:	Elrazi Ali, Mohammad Abu-Tineh, Anas Babiker, Yousef Hailan, Bashir Ali, Qusai Maharmah, Zakaria Maat, Abdulatif Waggad, Mohamed Yassin
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/be9085ae9f174c61b9d3fd19dbab8886
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spelling	oai:doaj.org-article:be9085ae9f174c61b9d3fd19dbab88862021-11-10T04:35:28ZTHE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE2531-137910.1016/j.htct.2021.10.1026https://doaj.org/article/be9085ae9f174c61b9d3fd19dbab88862021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011731https://doaj.org/toc/2531-1379Objective: The aim of this retrospective study is to evaluate fertility in the Philadelphia-negative MPN male patients and the effect of treatment received on male fertility and the outcome. Methodology: This is a single-center, mixed-design study (retrospective + phone interviews) conducted within the National Center for Cancer Care and Research. Results: 120 patients were interviewed, only 19 patients (15.7%) had met the inclusion criteria. The majority of patients had lost follow-up or cannot be contacted, and 29.1% of patients had their families completed by the time of diagnosis. The treatment received includes hydroxyurea, interferon, and ruxolitinib. The mode of delivery was normal vaginal delivery in 68% of the pregnancies. The total number of conceptions was 27; three stillbirths were reported. Conclusion: The data showed that most MPN male patients on treatment had their offspring born normally with no delivery complications, no reported congenital anomaly or growth retardation, and no report of MPN-related cancers. Though, further studies with a larger sample size are required to fully understand the effect of medications on the outcome of fatherhood in Philadelphia negative MPN patients.Elrazi AliMohammad Abu-TinehAnas BabikerYousef HailanBashir AliQusai MaharmahZakaria MaatAbdulatif WaggadMohamed YassinElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S39- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Elrazi Ali Mohammad Abu-Tineh Anas Babiker Yousef Hailan Bashir Ali Qusai Maharmah Zakaria Maat Abdulatif Waggad Mohamed Yassin THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE
description	Objective: The aim of this retrospective study is to evaluate fertility in the Philadelphia-negative MPN male patients and the effect of treatment received on male fertility and the outcome. Methodology: This is a single-center, mixed-design study (retrospective + phone interviews) conducted within the National Center for Cancer Care and Research. Results: 120 patients were interviewed, only 19 patients (15.7%) had met the inclusion criteria. The majority of patients had lost follow-up or cannot be contacted, and 29.1% of patients had their families completed by the time of diagnosis. The treatment received includes hydroxyurea, interferon, and ruxolitinib. The mode of delivery was normal vaginal delivery in 68% of the pregnancies. The total number of conceptions was 27; three stillbirths were reported. Conclusion: The data showed that most MPN male patients on treatment had their offspring born normally with no delivery complications, no reported congenital anomaly or growth retardation, and no report of MPN-related cancers. Though, further studies with a larger sample size are required to fully understand the effect of medications on the outcome of fatherhood in Philadelphia negative MPN patients.
format	article
author	Elrazi Ali Mohammad Abu-Tineh Anas Babiker Yousef Hailan Bashir Ali Qusai Maharmah Zakaria Maat Abdulatif Waggad Mohamed Yassin
author_facet	Elrazi Ali Mohammad Abu-Tineh Anas Babiker Yousef Hailan Bashir Ali Qusai Maharmah Zakaria Maat Abdulatif Waggad Mohamed Yassin
author_sort	Elrazi Ali
title	THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE
title_short	THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE
title_full	THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE
title_fullStr	THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE
title_full_unstemmed	THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE
title_sort	outcome of fatherhood in patients with philadelphia negative myeloproliferative neoplasms, a single institution experience
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/be9085ae9f174c61b9d3fd19dbab8886
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THE OUTCOME OF FATHERHOOD IN PATIENTS WITH PHILADELPHIA NEGATIVE MYELOPROLIFERATIVE NEOPLASMS, A SINGLE INSTITUTION EXPERIENCE

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