Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation

Abstract A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medical attention and care. In such a scenario, for the triage management by first res...

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Autores principales:	Anna Giovanetti, Raffaella Marconi, Noha Awad, Hala Abuzied, Neveen Agamy, Mohamed Barakat, Cecilia Bartoleschi, Gianluca Bossi, Marco Canfora, Amr A. Elsaid, Laura Ioannilli, Horeya M. Ismail, Yasmine Amr Issa, Flavia Novelli, Maria Chiara Pardini, Claudio Pioli, Paola Pinnarò, Giuseppe Sanguineti, Mohamed M. Tahoun, Riccardo Turchi, Lidia Strigari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be93ec5ae01f4b50af6c327db90398f8
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spelling	oai:doaj.org-article:be93ec5ae01f4b50af6c327db90398f82021-12-02T15:51:16ZValidation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation10.1038/s41598-021-87173-32045-2322https://doaj.org/article/be93ec5ae01f4b50af6c327db90398f82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87173-3https://doaj.org/toc/2045-2322Abstract A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medical attention and care. In such a scenario, for the triage management by first responders, it is necessary to count on efficient biological dosimetry tools capable of early detection of the absorbed dose. At present the validated assays for measuring the absorbed dose are dicentric chromosomes and micronuclei counts, which require more than 2–3 days to obtain results. To overcome this limitation the NATO SPS Programme funded an Italian–Egyptian collaborative project aimed at validating a fast, accurate and feasible tool for assessing the absorbed dose early after radiation exposure. Biomarkers as complete blood cell counts, DNA breaks and radio-inducible proteins were investigated on blood samples collected before and 3 h after the first fraction of radiotherapy in patients treated in specific target areas with doses/fraction of about: 2, 3.5 or > 5 Gy and compared with the reference micronuclei count. Based on univariate and multivariate multiple linear regression correlation, our results identify five early biomarkers potentially useful for detecting the extent of the absorbed dose 3 h after the exposure.Anna GiovanettiRaffaella MarconiNoha AwadHala AbuziedNeveen AgamyMohamed BarakatCecilia BartoleschiGianluca BossiMarco CanforaAmr A. ElsaidLaura IoannilliHoreya M. IsmailYasmine Amr IssaFlavia NovelliMaria Chiara PardiniClaudio PioliPaola PinnaròGiuseppe SanguinetiMohamed M. TahounRiccardo TurchiLidia StrigariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Giovanetti Raffaella Marconi Noha Awad Hala Abuzied Neveen Agamy Mohamed Barakat Cecilia Bartoleschi Gianluca Bossi Marco Canfora Amr A. Elsaid Laura Ioannilli Horeya M. Ismail Yasmine Amr Issa Flavia Novelli Maria Chiara Pardini Claudio Pioli Paola Pinnarò Giuseppe Sanguineti Mohamed M. Tahoun Riccardo Turchi Lidia Strigari Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
description	Abstract A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medical attention and care. In such a scenario, for the triage management by first responders, it is necessary to count on efficient biological dosimetry tools capable of early detection of the absorbed dose. At present the validated assays for measuring the absorbed dose are dicentric chromosomes and micronuclei counts, which require more than 2–3 days to obtain results. To overcome this limitation the NATO SPS Programme funded an Italian–Egyptian collaborative project aimed at validating a fast, accurate and feasible tool for assessing the absorbed dose early after radiation exposure. Biomarkers as complete blood cell counts, DNA breaks and radio-inducible proteins were investigated on blood samples collected before and 3 h after the first fraction of radiotherapy in patients treated in specific target areas with doses/fraction of about: 2, 3.5 or > 5 Gy and compared with the reference micronuclei count. Based on univariate and multivariate multiple linear regression correlation, our results identify five early biomarkers potentially useful for detecting the extent of the absorbed dose 3 h after the exposure.
format	article
author	Anna Giovanetti Raffaella Marconi Noha Awad Hala Abuzied Neveen Agamy Mohamed Barakat Cecilia Bartoleschi Gianluca Bossi Marco Canfora Amr A. Elsaid Laura Ioannilli Horeya M. Ismail Yasmine Amr Issa Flavia Novelli Maria Chiara Pardini Claudio Pioli Paola Pinnarò Giuseppe Sanguineti Mohamed M. Tahoun Riccardo Turchi Lidia Strigari
author_facet	Anna Giovanetti Raffaella Marconi Noha Awad Hala Abuzied Neveen Agamy Mohamed Barakat Cecilia Bartoleschi Gianluca Bossi Marco Canfora Amr A. Elsaid Laura Ioannilli Horeya M. Ismail Yasmine Amr Issa Flavia Novelli Maria Chiara Pardini Claudio Pioli Paola Pinnarò Giuseppe Sanguineti Mohamed M. Tahoun Riccardo Turchi Lidia Strigari
author_sort	Anna Giovanetti
title	Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
title_short	Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
title_full	Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
title_fullStr	Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
title_full_unstemmed	Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
title_sort	validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/be93ec5ae01f4b50af6c327db90398f8
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Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation

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