Exogene: A performant workflow for detecting viral integrations from paired-end next-generation sequencing data.

The integration of viruses into the human genome is known to be associated with tumorigenesis in many cancers, but the accurate detection of integration breakpoints from short read sequencing data is made difficult by human-viral homologies, viral genome heterogeneity, coverage limitations, and othe...

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Auteurs principaux: Zachary Stephens, Daniel O'Brien, Mrunal Dehankar, Lewis R Roberts, Ravishankar K Iyer, Jean-Pierre Kocher
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2021
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Accès en ligne:https://doaj.org/article/be96bb101e274e2d9e876b69d9b85acf
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