Therapeutic Implications of miRNAs for Muscle-Wasting Conditions

MicroRNAs (miRNAs) are small, non-coding RNA molecules that are mainly involved in translational repression by binding to specific messenger RNAs. Recently, miRNAs have emerged as biomarkers, relevant for a multitude of pathophysiological conditions, and cells can selectively sort miRNAs into extrac...

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Autores principales:	Laura Yedigaryan, Maurilio Sampaolesi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skeletal muscle regeneration miRNAs stem cells epigenetics inflammation muscle injury Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/be99b8c1fcc1451d9baa833db4878f33
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spelling	oai:doaj.org-article:be99b8c1fcc1451d9baa833db4878f332021-11-25T17:10:36ZTherapeutic Implications of miRNAs for Muscle-Wasting Conditions10.3390/cells101130352073-4409https://doaj.org/article/be99b8c1fcc1451d9baa833db4878f332021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3035https://doaj.org/toc/2073-4409MicroRNAs (miRNAs) are small, non-coding RNA molecules that are mainly involved in translational repression by binding to specific messenger RNAs. Recently, miRNAs have emerged as biomarkers, relevant for a multitude of pathophysiological conditions, and cells can selectively sort miRNAs into extracellular vesicles for paracrine and endocrine effects. In the overall context of muscle-wasting conditions, a multitude of miRNAs has been implied as being responsible for the typical dysregulation of anabolic and catabolic pathways. In general, chronic muscle disorders are associated with the main characteristic of a substantial loss in muscle mass. Muscular dystrophies (MDs) are a group of genetic diseases that cause muscle weakness and degeneration. Typically, MDs are caused by mutations in those genes responsible for upholding the integrity of muscle structure and function. Recently, the dysregulation of miRNA levels in such pathological conditions has been reported. This revelation is imperative for both MDs and other muscle-wasting conditions, such as sarcopenia and cancer cachexia. The expression levels of miRNAs have immense potential for use as potential diagnostic, prognostic and therapeutic biomarkers. Understanding the role of miRNAs in muscle-wasting conditions may lead to the development of novel strategies for the improvement of patient management.Laura YedigaryanMaurilio SampaolesiMDPI AGarticleskeletal muscle regenerationmiRNAsstem cellsepigeneticsinflammationmuscle injuryBiology (General)QH301-705.5ENCells, Vol 10, Iss 3035, p 3035 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skeletal muscle regeneration miRNAs stem cells epigenetics inflammation muscle injury Biology (General) QH301-705.5
spellingShingle	skeletal muscle regeneration miRNAs stem cells epigenetics inflammation muscle injury Biology (General) QH301-705.5 Laura Yedigaryan Maurilio Sampaolesi Therapeutic Implications of miRNAs for Muscle-Wasting Conditions
description	MicroRNAs (miRNAs) are small, non-coding RNA molecules that are mainly involved in translational repression by binding to specific messenger RNAs. Recently, miRNAs have emerged as biomarkers, relevant for a multitude of pathophysiological conditions, and cells can selectively sort miRNAs into extracellular vesicles for paracrine and endocrine effects. In the overall context of muscle-wasting conditions, a multitude of miRNAs has been implied as being responsible for the typical dysregulation of anabolic and catabolic pathways. In general, chronic muscle disorders are associated with the main characteristic of a substantial loss in muscle mass. Muscular dystrophies (MDs) are a group of genetic diseases that cause muscle weakness and degeneration. Typically, MDs are caused by mutations in those genes responsible for upholding the integrity of muscle structure and function. Recently, the dysregulation of miRNA levels in such pathological conditions has been reported. This revelation is imperative for both MDs and other muscle-wasting conditions, such as sarcopenia and cancer cachexia. The expression levels of miRNAs have immense potential for use as potential diagnostic, prognostic and therapeutic biomarkers. Understanding the role of miRNAs in muscle-wasting conditions may lead to the development of novel strategies for the improvement of patient management.
format	article
author	Laura Yedigaryan Maurilio Sampaolesi
author_facet	Laura Yedigaryan Maurilio Sampaolesi
author_sort	Laura Yedigaryan
title	Therapeutic Implications of miRNAs for Muscle-Wasting Conditions
title_short	Therapeutic Implications of miRNAs for Muscle-Wasting Conditions
title_full	Therapeutic Implications of miRNAs for Muscle-Wasting Conditions
title_fullStr	Therapeutic Implications of miRNAs for Muscle-Wasting Conditions
title_full_unstemmed	Therapeutic Implications of miRNAs for Muscle-Wasting Conditions
title_sort	therapeutic implications of mirnas for muscle-wasting conditions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/be99b8c1fcc1451d9baa833db4878f33
work_keys_str_mv	AT laurayedigaryan therapeuticimplicationsofmirnasformusclewastingconditions AT mauriliosampaolesi therapeuticimplicationsofmirnasformusclewastingconditions
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Therapeutic Implications of miRNAs for Muscle-Wasting Conditions

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