A Keller-Segel model for C elegans L1 aggregation.

We describe a mathematical model for the aggregation of starved first-stage C elegans larvae (L1s). We propose that starved L1s produce and respond chemotactically to two labile diffusible chemical signals, a short-range attractant and a longer range repellent. This model takes the mathematical form...

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Autores principales:	Leon Avery, Brian Ingalls, Catherine Dumur, Alexander Artyukhin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/be9bf7ec68a94de1a31719aec04d19bf
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spelling	oai:doaj.org-article:be9bf7ec68a94de1a31719aec04d19bf2021-12-02T19:57:21ZA Keller-Segel model for C elegans L1 aggregation.1553-734X1553-735810.1371/journal.pcbi.1009231https://doaj.org/article/be9bf7ec68a94de1a31719aec04d19bf2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009231https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358We describe a mathematical model for the aggregation of starved first-stage C elegans larvae (L1s). We propose that starved L1s produce and respond chemotactically to two labile diffusible chemical signals, a short-range attractant and a longer range repellent. This model takes the mathematical form of three coupled partial differential equations, one that describes the movement of the worms and one for each of the chemical signals. Numerical solution of these equations produced a pattern of aggregates that resembled that of worm aggregates observed in experiments. We also describe the identification of a sensory receptor gene, srh-2, whose expression is induced under conditions that promote L1 aggregation. Worms whose srh-2 gene has been knocked out form irregularly shaped aggregates. Our model suggests this phenotype may be explained by the mutant worms slowing their movement more quickly than the wild type.Leon AveryBrian IngallsCatherine DumurAlexander ArtyukhinPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009231 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Leon Avery Brian Ingalls Catherine Dumur Alexander Artyukhin A Keller-Segel model for C elegans L1 aggregation.
description	We describe a mathematical model for the aggregation of starved first-stage C elegans larvae (L1s). We propose that starved L1s produce and respond chemotactically to two labile diffusible chemical signals, a short-range attractant and a longer range repellent. This model takes the mathematical form of three coupled partial differential equations, one that describes the movement of the worms and one for each of the chemical signals. Numerical solution of these equations produced a pattern of aggregates that resembled that of worm aggregates observed in experiments. We also describe the identification of a sensory receptor gene, srh-2, whose expression is induced under conditions that promote L1 aggregation. Worms whose srh-2 gene has been knocked out form irregularly shaped aggregates. Our model suggests this phenotype may be explained by the mutant worms slowing their movement more quickly than the wild type.
format	article
author	Leon Avery Brian Ingalls Catherine Dumur Alexander Artyukhin
author_facet	Leon Avery Brian Ingalls Catherine Dumur Alexander Artyukhin
author_sort	Leon Avery
title	A Keller-Segel model for C elegans L1 aggregation.
title_short	A Keller-Segel model for C elegans L1 aggregation.
title_full	A Keller-Segel model for C elegans L1 aggregation.
title_fullStr	A Keller-Segel model for C elegans L1 aggregation.
title_full_unstemmed	A Keller-Segel model for C elegans L1 aggregation.
title_sort	keller-segel model for c elegans l1 aggregation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/be9bf7ec68a94de1a31719aec04d19bf
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A Keller-Segel model for C elegans L1 aggregation.

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