Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination

Synaptic inhibition in the olfactory bulb (OB) is believed to play a role in odour processing. Here, the authors use a Pcdh21-driven Cre-line to disrupt KCC2 expression in OB mitral cells and find altered synaptic connectivity along with disrupted separation of odour-induced activity patterns.

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Autores principales:	Kathrin Gödde, Olivier Gschwend, Dmytro Puchkov, Carsten K. Pfeffer, Alan Carleton, Thomas J. Jentsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be9c617d62544779bfba6f095f5f9b79
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spelling	oai:doaj.org-article:be9c617d62544779bfba6f095f5f9b792021-12-02T17:31:33ZDisruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination10.1038/ncomms120432041-1723https://doaj.org/article/be9c617d62544779bfba6f095f5f9b792016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12043https://doaj.org/toc/2041-1723Synaptic inhibition in the olfactory bulb (OB) is believed to play a role in odour processing. Here, the authors use a Pcdh21-driven Cre-line to disrupt KCC2 expression in OB mitral cells and find altered synaptic connectivity along with disrupted separation of odour-induced activity patterns.Kathrin GöddeOlivier GschwendDmytro PuchkovCarsten K. PfefferAlan CarletonThomas J. JentschNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathrin Gödde Olivier Gschwend Dmytro Puchkov Carsten K. Pfeffer Alan Carleton Thomas J. Jentsch Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
description	Synaptic inhibition in the olfactory bulb (OB) is believed to play a role in odour processing. Here, the authors use a Pcdh21-driven Cre-line to disrupt KCC2 expression in OB mitral cells and find altered synaptic connectivity along with disrupted separation of odour-induced activity patterns.
format	article
author	Kathrin Gödde Olivier Gschwend Dmytro Puchkov Carsten K. Pfeffer Alan Carleton Thomas J. Jentsch
author_facet	Kathrin Gödde Olivier Gschwend Dmytro Puchkov Carsten K. Pfeffer Alan Carleton Thomas J. Jentsch
author_sort	Kathrin Gödde
title	Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
title_short	Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
title_full	Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
title_fullStr	Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
title_full_unstemmed	Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
title_sort	disruption of kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/be9c617d62544779bfba6f095f5f9b79
work_keys_str_mv	AT kathringodde disruptionofkcc2dependentinhibitionofolfactorybulboutputneuronssuggestsitsimportanceinodourdiscrimination AT oliviergschwend disruptionofkcc2dependentinhibitionofolfactorybulboutputneuronssuggestsitsimportanceinodourdiscrimination AT dmytropuchkov disruptionofkcc2dependentinhibitionofolfactorybulboutputneuronssuggestsitsimportanceinodourdiscrimination AT carstenkpfeffer disruptionofkcc2dependentinhibitionofolfactorybulboutputneuronssuggestsitsimportanceinodourdiscrimination AT alancarleton disruptionofkcc2dependentinhibitionofolfactorybulboutputneuronssuggestsitsimportanceinodourdiscrimination AT thomasjjentsch disruptionofkcc2dependentinhibitionofolfactorybulboutputneuronssuggestsitsimportanceinodourdiscrimination
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Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination

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