Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination

Synaptic inhibition in the olfactory bulb (OB) is believed to play a role in odour processing. Here, the authors use a Pcdh21-driven Cre-line to disrupt KCC2 expression in OB mitral cells and find altered synaptic connectivity along with disrupted separation of odour-induced activity patterns.

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Autores principales: Kathrin Gödde, Olivier Gschwend, Dmytro Puchkov, Carsten K. Pfeffer, Alan Carleton, Thomas J. Jentsch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/be9c617d62544779bfba6f095f5f9b79
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