THz irradiation inhibits cell division by affecting actin dynamics.

Biological phenomena induced by terahertz (THz) irradiation are described in recent reports, but underlying mechanisms, structural and dynamical change of specific molecules are still unclear. In this paper, we performed time-lapse morphological analysis of human cells and found that THz irradiation...

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Autores principales:	Shota Yamazaki, Yuya Ueno, Ryosuke Hosoki, Takanori Saito, Toshitaka Idehara, Yuusuke Yamaguchi, Chiko Otani, Yuichi Ogawa, Masahiko Harata, Hiromichi Hoshina
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be9d5306ec1a407b9be7b349cad6aa49
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spelling	oai:doaj.org-article:be9d5306ec1a407b9be7b349cad6aa492021-12-02T20:15:20ZTHz irradiation inhibits cell division by affecting actin dynamics.1932-620310.1371/journal.pone.0248381https://doaj.org/article/be9d5306ec1a407b9be7b349cad6aa492021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0248381https://doaj.org/toc/1932-6203Biological phenomena induced by terahertz (THz) irradiation are described in recent reports, but underlying mechanisms, structural and dynamical change of specific molecules are still unclear. In this paper, we performed time-lapse morphological analysis of human cells and found that THz irradiation halts cell division at cytokinesis. At the end of cytokinesis, the contractile ring, which consists of filamentous actin (F-actin), needs to disappear; however, it remained for 1 hour under THz irradiation. Induction of the functional structures of F-actin was also observed in interphase cells. Similar phenomena were also observed under chemical treatment (jasplakinolide), indicating that THz irradiation assists actin polymerization. We previously reported that THz irradiation enhances the polymerization of purified actin in vitro; our current work shows that it increases cytoplasmic F-actin in vivo. Thus, we identified one of the key biomechanisms affected by THz waves.Shota YamazakiYuya UenoRyosuke HosokiTakanori SaitoToshitaka IdeharaYuusuke YamaguchiChiko OtaniYuichi OgawaMasahiko HarataHiromichi HoshinaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0248381 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shota Yamazaki Yuya Ueno Ryosuke Hosoki Takanori Saito Toshitaka Idehara Yuusuke Yamaguchi Chiko Otani Yuichi Ogawa Masahiko Harata Hiromichi Hoshina THz irradiation inhibits cell division by affecting actin dynamics.
description	Biological phenomena induced by terahertz (THz) irradiation are described in recent reports, but underlying mechanisms, structural and dynamical change of specific molecules are still unclear. In this paper, we performed time-lapse morphological analysis of human cells and found that THz irradiation halts cell division at cytokinesis. At the end of cytokinesis, the contractile ring, which consists of filamentous actin (F-actin), needs to disappear; however, it remained for 1 hour under THz irradiation. Induction of the functional structures of F-actin was also observed in interphase cells. Similar phenomena were also observed under chemical treatment (jasplakinolide), indicating that THz irradiation assists actin polymerization. We previously reported that THz irradiation enhances the polymerization of purified actin in vitro; our current work shows that it increases cytoplasmic F-actin in vivo. Thus, we identified one of the key biomechanisms affected by THz waves.
format	article
author	Shota Yamazaki Yuya Ueno Ryosuke Hosoki Takanori Saito Toshitaka Idehara Yuusuke Yamaguchi Chiko Otani Yuichi Ogawa Masahiko Harata Hiromichi Hoshina
author_facet	Shota Yamazaki Yuya Ueno Ryosuke Hosoki Takanori Saito Toshitaka Idehara Yuusuke Yamaguchi Chiko Otani Yuichi Ogawa Masahiko Harata Hiromichi Hoshina
author_sort	Shota Yamazaki
title	THz irradiation inhibits cell division by affecting actin dynamics.
title_short	THz irradiation inhibits cell division by affecting actin dynamics.
title_full	THz irradiation inhibits cell division by affecting actin dynamics.
title_fullStr	THz irradiation inhibits cell division by affecting actin dynamics.
title_full_unstemmed	THz irradiation inhibits cell division by affecting actin dynamics.
title_sort	thz irradiation inhibits cell division by affecting actin dynamics.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/be9d5306ec1a407b9be7b349cad6aa49
work_keys_str_mv	AT shotayamazaki thzirradiationinhibitscelldivisionbyaffectingactindynamics AT yuyaueno thzirradiationinhibitscelldivisionbyaffectingactindynamics AT ryosukehosoki thzirradiationinhibitscelldivisionbyaffectingactindynamics AT takanorisaito thzirradiationinhibitscelldivisionbyaffectingactindynamics AT toshitakaidehara thzirradiationinhibitscelldivisionbyaffectingactindynamics AT yuusukeyamaguchi thzirradiationinhibitscelldivisionbyaffectingactindynamics AT chikootani thzirradiationinhibitscelldivisionbyaffectingactindynamics AT yuichiogawa thzirradiationinhibitscelldivisionbyaffectingactindynamics AT masahikoharata thzirradiationinhibitscelldivisionbyaffectingactindynamics AT hiromichihoshina thzirradiationinhibitscelldivisionbyaffectingactindynamics
_version_	1718374606998339584

THz irradiation inhibits cell division by affecting actin dynamics.

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