Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.

Prepubertal testosterone levels are lower in intellectually gifted boys. The aim of this pilot study was to analyze potential genetic factors related to testosterone metabolism in control and gifted boys. Intellectually gifted (IQ>130; n = 95) and control (n = 67) boys were genotyped. Polymorphis...

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Autores principales:	Peter Celec, Denisa Tretinárová, Gabriel Minárik, Andrej Ficek, Tomáš Szemes, Silvia Lakatošová, Eva Schmidtová, Ján Turňa, Ľudevít Kádaši, Daniela Ostatníková
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/be9d8652a8de47b1aae630eb48239786
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spelling	oai:doaj.org-article:be9d8652a8de47b1aae630eb482397862021-11-18T07:59:31ZGenetic polymorphisms related to testosterone metabolism in intellectually gifted boys.1932-620310.1371/journal.pone.0054751https://doaj.org/article/be9d8652a8de47b1aae630eb482397862013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382957/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Prepubertal testosterone levels are lower in intellectually gifted boys. The aim of this pilot study was to analyze potential genetic factors related to testosterone metabolism in control and gifted boys. Intellectually gifted (IQ>130; n = 95) and control (n = 67) boys were genotyped. Polymorphisms of interests were chosen in genes including androgen and estrogen receptors, 5-alpha reductase, aromatase and sex hormone binding globulin. Significant differences between control and gifted boys in genotype distributions were found for ESR2 (rs928554) and SHBG (rs1799941). A significantly lower number of CAG repeats in the AR gene were found in gifted boys. Our results support the role of genetic factors related to testosterone metabolism in intellectual giftedness. Increased androgen signaling might explain previous results of lower testosterone levels in intellectually gifted boys and add to the understanding of variability in cognitive abilities.Peter CelecDenisa TretinárováGabriel MinárikAndrej FicekTomáš SzemesSilvia LakatošováEva SchmidtováJán TurňaĽudevít KádašiDaniela OstatníkováPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54751 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter Celec Denisa Tretinárová Gabriel Minárik Andrej Ficek Tomáš Szemes Silvia Lakatošová Eva Schmidtová Ján Turňa Ľudevít Kádaši Daniela Ostatníková Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
description	Prepubertal testosterone levels are lower in intellectually gifted boys. The aim of this pilot study was to analyze potential genetic factors related to testosterone metabolism in control and gifted boys. Intellectually gifted (IQ>130; n = 95) and control (n = 67) boys were genotyped. Polymorphisms of interests were chosen in genes including androgen and estrogen receptors, 5-alpha reductase, aromatase and sex hormone binding globulin. Significant differences between control and gifted boys in genotype distributions were found for ESR2 (rs928554) and SHBG (rs1799941). A significantly lower number of CAG repeats in the AR gene were found in gifted boys. Our results support the role of genetic factors related to testosterone metabolism in intellectual giftedness. Increased androgen signaling might explain previous results of lower testosterone levels in intellectually gifted boys and add to the understanding of variability in cognitive abilities.
format	article
author	Peter Celec Denisa Tretinárová Gabriel Minárik Andrej Ficek Tomáš Szemes Silvia Lakatošová Eva Schmidtová Ján Turňa Ľudevít Kádaši Daniela Ostatníková
author_facet	Peter Celec Denisa Tretinárová Gabriel Minárik Andrej Ficek Tomáš Szemes Silvia Lakatošová Eva Schmidtová Ján Turňa Ľudevít Kádaši Daniela Ostatníková
author_sort	Peter Celec
title	Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
title_short	Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
title_full	Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
title_fullStr	Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
title_full_unstemmed	Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
title_sort	genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/be9d8652a8de47b1aae630eb48239786
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Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys.

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