A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

Upon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its removal is mediated by the same protease. Here the authors show that ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation of ATG4 regulates its cellular activity to...

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Autores principales:	N. Pengo, A. Agrotis, K. Prak, J. Jones, R. Ketteler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be9d8c9445e94d1a89cc7a77d68e8daf
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spelling	oai:doaj.org-article:be9d8c9445e94d1a89cc7a77d68e8daf2021-12-02T13:57:54ZA reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B10.1038/s41467-017-00303-22041-1723https://doaj.org/article/be9d8c9445e94d1a89cc7a77d68e8daf2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00303-2https://doaj.org/toc/2041-1723Upon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its removal is mediated by the same protease. Here the authors show that ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation of ATG4 regulates its cellular activity to control LC3 processing.N. PengoA. AgrotisK. PrakJ. JonesR. KettelerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. Pengo A. Agrotis K. Prak J. Jones R. Ketteler A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
description	Upon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its removal is mediated by the same protease. Here the authors show that ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation of ATG4 regulates its cellular activity to control LC3 processing.
format	article
author	N. Pengo A. Agrotis K. Prak J. Jones R. Ketteler
author_facet	N. Pengo A. Agrotis K. Prak J. Jones R. Ketteler
author_sort	N. Pengo
title	A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_short	A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_full	A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_fullStr	A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_full_unstemmed	A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_sort	reversible phospho-switch mediated by ulk1 regulates the activity of autophagy protease atg4b
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/be9d8c9445e94d1a89cc7a77d68e8daf
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A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

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