Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study

Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed to examine the relationship between PCSK9 concentration, coagulation ind...

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Autores principales:	Jia Peng, Ming-Ming Liu, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong, Jie Qian, Ke-Fei Dou, Cheng-Gang Zhu, Jian-Jun Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	PCSK9 Coagulation PT Atherosclerosis Cardiovascular risks Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/bea076379c8d41b38664a1978ae0363b
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spelling	oai:doaj.org-article:bea076379c8d41b38664a1978ae0363b2021-11-28T12:25:31ZAssociation of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study10.1186/s12959-021-00344-01477-9560https://doaj.org/article/bea076379c8d41b38664a1978ae0363b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12959-021-00344-0https://doaj.org/toc/1477-9560Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed to examine the relationship between PCSK9 concentration, coagulation indexes and cardiovascular events. Methods A total of 2293 consecutive patients with angina-like chest pain and without lipid-lowering drugs treatment were enrolled and followed up for major adverse cardiovascular events (MACEs). Circulating PCSK9 concentration was determined by ELISA. The routine coagulation tests including activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time were performed. The associations between PCSK9 concentration, routine coagulation indicators and MACEs were analyzed. Results Patients with high PCSK9 levels had lower PT and APTT levels (all p < 0.05). However, PCSK9 concentration was only independently and negatively correlated with PT (β = − 0.115, p < 0.001). During a mean of 38.3 months, 186 (8.1%) MACEs were occurred. Multiple Cox regression analysis indicated high PCSK9 or low PT levels as risk factors related to MACEs. When the prognosis was analyzed by the combination of PCSK9 and PT levels, patients with high PCSK9 and low PT had higher incidence of MACEs compared to those with low PCSK9 and high PT. Conclusions Our study firstly suggested that PCSK9 concentration was negatively correlated with plasma levels of PT. Furthermore, high PCSK9 and low PT were associated with MACEs and the combination of PCSK9 with PT had an addictive effect on predicting cardiovascular outcomes in patients with chest pain, which was useful for further subdivision of cardiovascular risks.Jia PengMing-Ming LiuHui-Hui LiuYuan-Lin GuoNa-Qiong WuQian DongJie QianKe-Fei DouCheng-Gang ZhuJian-Jun LiBMCarticlePCSK9CoagulationPTAtherosclerosisCardiovascular risksDiseases of the blood and blood-forming organsRC633-647.5ENThrombosis Journal, Vol 19, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PCSK9 Coagulation PT Atherosclerosis Cardiovascular risks Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	PCSK9 Coagulation PT Atherosclerosis Cardiovascular risks Diseases of the blood and blood-forming organs RC633-647.5 Jia Peng Ming-Ming Liu Hui-Hui Liu Yuan-Lin Guo Na-Qiong Wu Qian Dong Jie Qian Ke-Fei Dou Cheng-Gang Zhu Jian-Jun Li Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
description	Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed to examine the relationship between PCSK9 concentration, coagulation indexes and cardiovascular events. Methods A total of 2293 consecutive patients with angina-like chest pain and without lipid-lowering drugs treatment were enrolled and followed up for major adverse cardiovascular events (MACEs). Circulating PCSK9 concentration was determined by ELISA. The routine coagulation tests including activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time were performed. The associations between PCSK9 concentration, routine coagulation indicators and MACEs were analyzed. Results Patients with high PCSK9 levels had lower PT and APTT levels (all p < 0.05). However, PCSK9 concentration was only independently and negatively correlated with PT (β = − 0.115, p < 0.001). During a mean of 38.3 months, 186 (8.1%) MACEs were occurred. Multiple Cox regression analysis indicated high PCSK9 or low PT levels as risk factors related to MACEs. When the prognosis was analyzed by the combination of PCSK9 and PT levels, patients with high PCSK9 and low PT had higher incidence of MACEs compared to those with low PCSK9 and high PT. Conclusions Our study firstly suggested that PCSK9 concentration was negatively correlated with plasma levels of PT. Furthermore, high PCSK9 and low PT were associated with MACEs and the combination of PCSK9 with PT had an addictive effect on predicting cardiovascular outcomes in patients with chest pain, which was useful for further subdivision of cardiovascular risks.
format	article
author	Jia Peng Ming-Ming Liu Hui-Hui Liu Yuan-Lin Guo Na-Qiong Wu Qian Dong Jie Qian Ke-Fei Dou Cheng-Gang Zhu Jian-Jun Li
author_facet	Jia Peng Ming-Ming Liu Hui-Hui Liu Yuan-Lin Guo Na-Qiong Wu Qian Dong Jie Qian Ke-Fei Dou Cheng-Gang Zhu Jian-Jun Li
author_sort	Jia Peng
title	Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
title_short	Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
title_full	Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
title_fullStr	Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
title_full_unstemmed	Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
title_sort	association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bea076379c8d41b38664a1978ae0363b
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Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study

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