High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content

Exercise training can be therapeutic but how mitochondria respond remains unclear. Here, the authors use multiple omics techniques to reveal a complex network of non-stoichiometric mitochondrial adaptations that are prioritized or deprioritised during different phases of exercise training.

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Autores principales:	Cesare Granata, Nikeisha J. Caruana, Javier Botella, Nicholas A. Jamnick, Kevin Huynh, Jujiao Kuang, Hans A. Janssen, Boris Reljic, Natalie A. Mellett, Adrienne Laskowski, Tegan L. Stait, Ann E. Frazier, Melinda T. Coughlan, Peter J. Meikle, David R. Thorburn, David A. Stroud, David J. Bishop
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bea2037780444510914f0ea9d4120a6f
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spelling	oai:doaj.org-article:bea2037780444510914f0ea9d4120a6f2021-12-05T12:22:06ZHigh-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content10.1038/s41467-021-27153-32041-1723https://doaj.org/article/bea2037780444510914f0ea9d4120a6f2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27153-3https://doaj.org/toc/2041-1723Exercise training can be therapeutic but how mitochondria respond remains unclear. Here, the authors use multiple omics techniques to reveal a complex network of non-stoichiometric mitochondrial adaptations that are prioritized or deprioritised during different phases of exercise training.Cesare GranataNikeisha J. CaruanaJavier BotellaNicholas A. JamnickKevin HuynhJujiao KuangHans A. JanssenBoris ReljicNatalie A. MellettAdrienne LaskowskiTegan L. StaitAnn E. FrazierMelinda T. CoughlanPeter J. MeikleDavid R. ThorburnDavid A. StroudDavid J. BishopNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cesare Granata Nikeisha J. Caruana Javier Botella Nicholas A. Jamnick Kevin Huynh Jujiao Kuang Hans A. Janssen Boris Reljic Natalie A. Mellett Adrienne Laskowski Tegan L. Stait Ann E. Frazier Melinda T. Coughlan Peter J. Meikle David R. Thorburn David A. Stroud David J. Bishop High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
description	Exercise training can be therapeutic but how mitochondria respond remains unclear. Here, the authors use multiple omics techniques to reveal a complex network of non-stoichiometric mitochondrial adaptations that are prioritized or deprioritised during different phases of exercise training.
format	article
author	Cesare Granata Nikeisha J. Caruana Javier Botella Nicholas A. Jamnick Kevin Huynh Jujiao Kuang Hans A. Janssen Boris Reljic Natalie A. Mellett Adrienne Laskowski Tegan L. Stait Ann E. Frazier Melinda T. Coughlan Peter J. Meikle David R. Thorburn David A. Stroud David J. Bishop
author_facet	Cesare Granata Nikeisha J. Caruana Javier Botella Nicholas A. Jamnick Kevin Huynh Jujiao Kuang Hans A. Janssen Boris Reljic Natalie A. Mellett Adrienne Laskowski Tegan L. Stait Ann E. Frazier Melinda T. Coughlan Peter J. Meikle David R. Thorburn David A. Stroud David J. Bishop
author_sort	Cesare Granata
title	High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
title_short	High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
title_full	High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
title_fullStr	High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
title_full_unstemmed	High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
title_sort	high-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bea2037780444510914f0ea9d4120a6f
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High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content

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