Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TE...

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Autores principales:	Thomas Barthlott, Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H. Orkin, Jean-Pierre de Villartay, Stephen R. Daley, Georg A. Holländer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bea5fbe30e2340e383f4864410b7a2fd
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spelling	oai:doaj.org-article:bea5fbe30e2340e383f4864410b7a2fd2021-12-02T18:02:51ZIndispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 210.1038/s41467-021-24158-w2041-1723https://doaj.org/article/bea5fbe30e2340e383f4864410b7a2fd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24158-whttps://doaj.org/toc/2041-1723Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TEC subset, and hampers T cell development.Thomas BarthlottAdam E. HandelHong Ying TehRushika C. WirasinhaKatrin HafenSaulius ŽuklysBenoit RochStuart H. OrkinJean-Pierre de VillartayStephen R. DaleyGeorg A. HolländerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Barthlott Adam E. Handel Hong Ying Teh Rushika C. Wirasinha Katrin Hafen Saulius Žuklys Benoit Roch Stuart H. Orkin Jean-Pierre de Villartay Stephen R. Daley Georg A. Holländer Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
description	Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TEC subset, and hampers T cell development.
format	article
author	Thomas Barthlott Adam E. Handel Hong Ying Teh Rushika C. Wirasinha Katrin Hafen Saulius Žuklys Benoit Roch Stuart H. Orkin Jean-Pierre de Villartay Stephen R. Daley Georg A. Holländer
author_facet	Thomas Barthlott Adam E. Handel Hong Ying Teh Rushika C. Wirasinha Katrin Hafen Saulius Žuklys Benoit Roch Stuart H. Orkin Jean-Pierre de Villartay Stephen R. Daley Georg A. Holländer
author_sort	Thomas Barthlott
title	Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
title_short	Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
title_full	Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
title_fullStr	Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
title_full_unstemmed	Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
title_sort	indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bea5fbe30e2340e383f4864410b7a2fd
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Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

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