Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder

Abstract This study was to explore the sex differences in clinical characteristics and brain gray matter volume (GMV) alterations in 29 male patients with major depressive disorder (MDDm), 53 female patients with MDD (MDDf), and in 29 male and 53 female matched healthy controls. Maps of GMV were con...

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Autores principales:	Xiao Yang, Zugui Peng, Xiaojuan Ma, Yajing Meng, Mingli Li, Jian Zhang, Xiuliu Song, Ye Liu, Huanhuan Fan, Liansheng Zhao, Wei Deng, Tao Li, Xiaohong Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bea6c212fd86473487f621fe9b929dd3
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spelling	oai:doaj.org-article:bea6c212fd86473487f621fe9b929dd32021-12-02T15:05:57ZSex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder10.1038/s41598-017-02828-42045-2322https://doaj.org/article/bea6c212fd86473487f621fe9b929dd32017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02828-4https://doaj.org/toc/2045-2322Abstract This study was to explore the sex differences in clinical characteristics and brain gray matter volume (GMV) alterations in 29 male patients with major depressive disorder (MDDm), 53 female patients with MDD (MDDf), and in 29 male and 53 female matched healthy controls. Maps of GMV were constructed using magnetic resonance imaging data and compared between groups. We evaluated clinical symptoms using the Hamilton Rating Scale for Depression and obtained a total score and five syndrome scores. A two-factor ANCOVA model was specified using SPM8, with sex and diagnosis as the between-subject factors. We found that: (1) significant GMV increase in the left cerebellum and GMV reduction in the bilateral middle temporal gyrus and left ventral medial prefrontal gyrus occurred selectively in male patients, while the GMV reduction in the left lingual gyrus and dorsal medial prefrontal gyrus occurred selectively in female patients; (2) MDDf may have experienced more severe sleep disturbance than MDDm; and (3) the severity of sleep symptom could be predicted by the sex specific brain structural alterations in depressions. These findings suggest that sex specific anatomical alterations existed in MDD, and these alterations were associated with the clinical symptoms.Xiao YangZugui PengXiaojuan MaYajing MengMingli LiJian ZhangXiuliu SongYe LiuHuanhuan FanLiansheng ZhaoWei DengTao LiXiaohong MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiao Yang Zugui Peng Xiaojuan Ma Yajing Meng Mingli Li Jian Zhang Xiuliu Song Ye Liu Huanhuan Fan Liansheng Zhao Wei Deng Tao Li Xiaohong Ma Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder
description	Abstract This study was to explore the sex differences in clinical characteristics and brain gray matter volume (GMV) alterations in 29 male patients with major depressive disorder (MDDm), 53 female patients with MDD (MDDf), and in 29 male and 53 female matched healthy controls. Maps of GMV were constructed using magnetic resonance imaging data and compared between groups. We evaluated clinical symptoms using the Hamilton Rating Scale for Depression and obtained a total score and five syndrome scores. A two-factor ANCOVA model was specified using SPM8, with sex and diagnosis as the between-subject factors. We found that: (1) significant GMV increase in the left cerebellum and GMV reduction in the bilateral middle temporal gyrus and left ventral medial prefrontal gyrus occurred selectively in male patients, while the GMV reduction in the left lingual gyrus and dorsal medial prefrontal gyrus occurred selectively in female patients; (2) MDDf may have experienced more severe sleep disturbance than MDDm; and (3) the severity of sleep symptom could be predicted by the sex specific brain structural alterations in depressions. These findings suggest that sex specific anatomical alterations existed in MDD, and these alterations were associated with the clinical symptoms.
format	article
author	Xiao Yang Zugui Peng Xiaojuan Ma Yajing Meng Mingli Li Jian Zhang Xiuliu Song Ye Liu Huanhuan Fan Liansheng Zhao Wei Deng Tao Li Xiaohong Ma
author_facet	Xiao Yang Zugui Peng Xiaojuan Ma Yajing Meng Mingli Li Jian Zhang Xiuliu Song Ye Liu Huanhuan Fan Liansheng Zhao Wei Deng Tao Li Xiaohong Ma
author_sort	Xiao Yang
title	Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder
title_short	Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder
title_full	Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder
title_fullStr	Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder
title_full_unstemmed	Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder
title_sort	sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bea6c212fd86473487f621fe9b929dd3
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Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder

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