Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

Ric8A regulates G protein α-subunits (Gα) by acting as a guanine nucleotide exchange factor (GEF) and a Gα chaperone. Here, the authors solve the crystal structures of free and Gα fragment bound Ric8A, and provide insights into the structural basis for Ric8A’s GEF and chaperone functions.

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Autores principales:	Dhiraj Srivastava, Lokesh Gakhar, Nikolai O. Artemyev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bea98bc56e5b4376a6be5042e63b46f6
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spelling	oai:doaj.org-article:bea98bc56e5b4376a6be5042e63b46f62021-12-02T15:35:13ZStructural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor10.1038/s41467-019-11088-x2041-1723https://doaj.org/article/bea98bc56e5b4376a6be5042e63b46f62019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11088-xhttps://doaj.org/toc/2041-1723Ric8A regulates G protein α-subunits (Gα) by acting as a guanine nucleotide exchange factor (GEF) and a Gα chaperone. Here, the authors solve the crystal structures of free and Gα fragment bound Ric8A, and provide insights into the structural basis for Ric8A’s GEF and chaperone functions.Dhiraj SrivastavaLokesh GakharNikolai O. ArtemyevNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dhiraj Srivastava Lokesh Gakhar Nikolai O. Artemyev Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
description	Ric8A regulates G protein α-subunits (Gα) by acting as a guanine nucleotide exchange factor (GEF) and a Gα chaperone. Here, the authors solve the crystal structures of free and Gα fragment bound Ric8A, and provide insights into the structural basis for Ric8A’s GEF and chaperone functions.
format	article
author	Dhiraj Srivastava Lokesh Gakhar Nikolai O. Artemyev
author_facet	Dhiraj Srivastava Lokesh Gakhar Nikolai O. Artemyev
author_sort	Dhiraj Srivastava
title	Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
title_short	Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
title_full	Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
title_fullStr	Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
title_full_unstemmed	Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
title_sort	structural underpinnings of ric8a function as a g-protein α-subunit chaperone and guanine-nucleotide exchange factor
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bea98bc56e5b4376a6be5042e63b46f6
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Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

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