Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China

Abstract Dyslipidemia is one of the main risk factors for coronary heart disease (CHD). The E3 ubiquitin ligase which is encoded by the ring finger protein 145 (RNF145) gene is very important in the mediation of cholesterol synthesis and effectively treats hypercholesterolemia. Thus, the purpose of...

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Autores principales:	Jing Ming, Xian Wei, Min Han, Dilare Adi, Jialin Abuzhalihan, Yong-Tao Wang, Yi-Ning Yang, Xiao-Mei Li, Xiang Xie, Zhen-Yan Fu, Min-Tao Gai, Yi-Tong Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/beaab26d5c494f819e8806c95b234ce0
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spelling	oai:doaj.org-article:beaab26d5c494f819e8806c95b234ce02021-12-02T17:05:49ZGenetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China10.1038/s41598-021-85503-z2045-2322https://doaj.org/article/beaab26d5c494f819e8806c95b234ce02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85503-zhttps://doaj.org/toc/2045-2322Abstract Dyslipidemia is one of the main risk factors for coronary heart disease (CHD). The E3 ubiquitin ligase which is encoded by the ring finger protein 145 (RNF145) gene is very important in the mediation of cholesterol synthesis and effectively treats hypercholesterolemia. Thus, the purpose of the present research is to investigate the connection between the polymorphism of the RNF145 gene and cholesterol levels in the populations in Xinjiang, China. A total of 1396 participants (Male: 628, Female: 768) were included in this study for genetic analysis of RNF145 gene, and we used the modified multiple connection detection response (iMLDR) technology to label two SNPs (rs17056583, rs12188266) of RNF145 genotyping. The relationship between the genotypes and the lipid profiles was analyzed with general linear model analysis after adjusting confounding variables. Through the analysis of the two SNPs in RNF145 gene, we discovered that both rs17056583 and rs12188266 were related to total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations (All P < 0.001). In addition, the association of rs17056583 and rs12188266 with lipid profiles concentrations is still statistically significant after multivariate adjustment of sex, age, smoking, obesity, drinking, diabetes, hypertension and lipid profiles. Meanwhile, we also found that rs17056583 was associated with high triglycerides concentrations before and after adjustment (All P < 0.001). Our study shows that both rs17056583 and rs12188266 SNPs of RNP145 gene are related to TC and LDL-C concentrations in Xinjiang population.Jing MingXian WeiMin HanDilare AdiJialin AbuzhalihanYong-Tao WangYi-Ning YangXiao-Mei LiXiang XieZhen-Yan FuMin-Tao GaiYi-Tong MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Ming Xian Wei Min Han Dilare Adi Jialin Abuzhalihan Yong-Tao Wang Yi-Ning Yang Xiao-Mei Li Xiang Xie Zhen-Yan Fu Min-Tao Gai Yi-Tong Ma Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
description	Abstract Dyslipidemia is one of the main risk factors for coronary heart disease (CHD). The E3 ubiquitin ligase which is encoded by the ring finger protein 145 (RNF145) gene is very important in the mediation of cholesterol synthesis and effectively treats hypercholesterolemia. Thus, the purpose of the present research is to investigate the connection between the polymorphism of the RNF145 gene and cholesterol levels in the populations in Xinjiang, China. A total of 1396 participants (Male: 628, Female: 768) were included in this study for genetic analysis of RNF145 gene, and we used the modified multiple connection detection response (iMLDR) technology to label two SNPs (rs17056583, rs12188266) of RNF145 genotyping. The relationship between the genotypes and the lipid profiles was analyzed with general linear model analysis after adjusting confounding variables. Through the analysis of the two SNPs in RNF145 gene, we discovered that both rs17056583 and rs12188266 were related to total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations (All P < 0.001). In addition, the association of rs17056583 and rs12188266 with lipid profiles concentrations is still statistically significant after multivariate adjustment of sex, age, smoking, obesity, drinking, diabetes, hypertension and lipid profiles. Meanwhile, we also found that rs17056583 was associated with high triglycerides concentrations before and after adjustment (All P < 0.001). Our study shows that both rs17056583 and rs12188266 SNPs of RNP145 gene are related to TC and LDL-C concentrations in Xinjiang population.
format	article
author	Jing Ming Xian Wei Min Han Dilare Adi Jialin Abuzhalihan Yong-Tao Wang Yi-Ning Yang Xiao-Mei Li Xiang Xie Zhen-Yan Fu Min-Tao Gai Yi-Tong Ma
author_facet	Jing Ming Xian Wei Min Han Dilare Adi Jialin Abuzhalihan Yong-Tao Wang Yi-Ning Yang Xiao-Mei Li Xiang Xie Zhen-Yan Fu Min-Tao Gai Yi-Tong Ma
author_sort	Jing Ming
title	Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
title_short	Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
title_full	Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
title_fullStr	Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
title_full_unstemmed	Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China
title_sort	genetic variation of rnf145 gene and blood lipid levels in xinjiang population, china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/beaab26d5c494f819e8806c95b234ce0
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Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China

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