Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling PathwaySummary

Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling PathwaySummary

Background & Aims: Sustained c-Jun N-terminal kinase (JNK) activation plays a major role in drug-induced liver injury (DILI). Stress-responsive microRNA-31 (miR-31) has been implicated in regulating different cellular damage, and JNK activation could induce miR-31 expression. However, the re...

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Bibliographic Details
Main Authors: Jianxin Zheng, Hong Zhou, Taihua Yang, Jinchuan Liu, Tian Qin, Xiangqian Gu, Ji Wu, Yi Zhang, Honglin Wang, Yuanjia Tang, Feng Xue, Yimin Mao, Qiang Xia
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
microRNA
Drug-Induced Liver Injury
Damage Responsive
Negative Feedback
Necrosis
Diseases of the digestive system. Gastroenterology
RC799-869
Online Access:https://doaj.org/article/beabaa901cb04e698d21b5567b0393e5
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https://doaj.org/article/beabaa901cb04e698d21b5567b0393e5

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