Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy

Tomoaki Higashiyama,1 Yasuhiro Nishida,2 Masahito Ohji1 1Department of Ophthalmology, 2Clinical Medical Education Center, Shiga University of Medical Science, Shiga, Japan Purpose: To characterize the relationship between inflammation and swelling of extraocular muscles in thyroid-associated ophth...

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Autores principales:	Higashiyama T, Nishida Y, Ohji M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	thyroid-associated ophthalmopathy methylprednisolone pulse therapy extraocular muscle magnetic resonance imaging signal intensity volume. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bead7f433db24688a65ce314972e674a
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spelling	oai:doaj.org-article:bead7f433db24688a65ce314972e674a2021-12-02T00:25:52ZRelationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy1177-5483https://doaj.org/article/bead7f433db24688a65ce314972e674a2016-04-01T00:00:00Zhttps://www.dovepress.com/relationship-between-magnetic-resonance-imaging-signal-intensity-and-v-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tomoaki Higashiyama,1 Yasuhiro Nishida,2 Masahito Ohji1 1Department of Ophthalmology, 2Clinical Medical Education Center, Shiga University of Medical Science, Shiga, Japan Purpose: To characterize the relationship between inflammation and swelling of extraocular muscles in thyroid-associated ophthalmopathy before and after methylprednisolone pulse therapy.Methods: The signal intensities and volumes of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured with magnetic resonance imaging in 25 eyes of 25 patients with thyroid-associated ophthalmopathy in the acute inflammatory phase before and after methylprednisolone pulse therapy. The signal intensity ratios (SIRs) of muscles and brain white matter were calculated.Result: The mean SIRs before treatment were 2.28±0.74 in SR, 2.66±0.57 in IR, 2.03±0.42 in LR, 2.45±0.49 in MR, and 1.98±0.48 in SO muscles. The mean SIRs after treatment were 1.82±0.62, 1.84±0.52, 1.70±0.35, 1.95±0.46, and 1.60±0.36, respectively. The mean volumes (cm3) before treatment were 1.35±0.67 in SR, 1.21±0.39 in IR, 0.66±0.13 in LR, 0.94±0.31 in MR, and 0.58±0.14 in SO muscles. Those after treatment were 1.12±0.45, 0.91±0.31, 0.61±0.12, 0.85±0.28, and 0.49±0.11, respectively. The SIRs showed significantly positive correlations with volumes both before and after treatment in SR muscles (before, r=0.77; after, r=0.69), IR muscles (before, r=0.65; after, r=0.60), MR muscles (before, r=0.69; after, r=0.73), and SO muscles (before, r=0.52; after, r=0.50) (P<0.01 for all correlations).Conclusion: Swelling reflected the inflammation in extraocular muscles of thyroid-associated ophthalmopathy both before and after treatment. Keywords: thyroid-associated ophthalmopathy, methylprednisolone pulse therapy, extraocular muscle, magnetic resonance imaging, signal intensity, volume Higashiyama TNishida YOhji MDove Medical Pressarticlethyroid-associated ophthalmopathymethylprednisolone pulse therapyextraocular musclemagnetic resonance imagingsignal intensityvolume.OphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 721-729 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid-associated ophthalmopathy methylprednisolone pulse therapy extraocular muscle magnetic resonance imaging signal intensity volume. Ophthalmology RE1-994
spellingShingle	thyroid-associated ophthalmopathy methylprednisolone pulse therapy extraocular muscle magnetic resonance imaging signal intensity volume. Ophthalmology RE1-994 Higashiyama T Nishida Y Ohji M Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy
description	Tomoaki Higashiyama,1 Yasuhiro Nishida,2 Masahito Ohji1 1Department of Ophthalmology, 2Clinical Medical Education Center, Shiga University of Medical Science, Shiga, Japan Purpose: To characterize the relationship between inflammation and swelling of extraocular muscles in thyroid-associated ophthalmopathy before and after methylprednisolone pulse therapy.Methods: The signal intensities and volumes of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured with magnetic resonance imaging in 25 eyes of 25 patients with thyroid-associated ophthalmopathy in the acute inflammatory phase before and after methylprednisolone pulse therapy. The signal intensity ratios (SIRs) of muscles and brain white matter were calculated.Result: The mean SIRs before treatment were 2.28±0.74 in SR, 2.66±0.57 in IR, 2.03±0.42 in LR, 2.45±0.49 in MR, and 1.98±0.48 in SO muscles. The mean SIRs after treatment were 1.82±0.62, 1.84±0.52, 1.70±0.35, 1.95±0.46, and 1.60±0.36, respectively. The mean volumes (cm3) before treatment were 1.35±0.67 in SR, 1.21±0.39 in IR, 0.66±0.13 in LR, 0.94±0.31 in MR, and 0.58±0.14 in SO muscles. Those after treatment were 1.12±0.45, 0.91±0.31, 0.61±0.12, 0.85±0.28, and 0.49±0.11, respectively. The SIRs showed significantly positive correlations with volumes both before and after treatment in SR muscles (before, r=0.77; after, r=0.69), IR muscles (before, r=0.65; after, r=0.60), MR muscles (before, r=0.69; after, r=0.73), and SO muscles (before, r=0.52; after, r=0.50) (P<0.01 for all correlations).Conclusion: Swelling reflected the inflammation in extraocular muscles of thyroid-associated ophthalmopathy both before and after treatment. Keywords: thyroid-associated ophthalmopathy, methylprednisolone pulse therapy, extraocular muscle, magnetic resonance imaging, signal intensity, volume
format	article
author	Higashiyama T Nishida Y Ohji M
author_facet	Higashiyama T Nishida Y Ohji M
author_sort	Higashiyama T
title	Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy
title_short	Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy
title_full	Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy
title_fullStr	Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy
title_full_unstemmed	Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy
title_sort	relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/bead7f433db24688a65ce314972e674a
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Relationship between magnetic resonance imaging signal intensity and volume of extraocular muscles in thyroid-associated ophthalmopathy with methylprednisolone pulse therapy

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