Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Xist RNA is required for X chromosome inactivation but it is not well understood how Xist silences some regions more efficiently than others. Here, the authors induce ectopic Xist expression from multiple different X-linked and autosomal loci in cells to explore Xist function.

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Autores principales:	Agnese Loda, Johannes H. Brandsma, Ivaylo Vassilev, Nicolas Servant, Friedemann Loos, Azadeh Amirnasr, Erik Splinter, Emmanuel Barillot, Raymond A. Poot, Edith Heard, Joost Gribnau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bead8e222125434f8fcd1ca116a4f245
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spelling	oai:doaj.org-article:bead8e222125434f8fcd1ca116a4f2452021-12-02T17:01:18ZGenetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations10.1038/s41467-017-00528-12041-1723https://doaj.org/article/bead8e222125434f8fcd1ca116a4f2452017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00528-1https://doaj.org/toc/2041-1723Xist RNA is required for X chromosome inactivation but it is not well understood how Xist silences some regions more efficiently than others. Here, the authors induce ectopic Xist expression from multiple different X-linked and autosomal loci in cells to explore Xist function.Agnese LodaJohannes H. BrandsmaIvaylo VassilevNicolas ServantFriedemann LoosAzadeh AmirnasrErik SplinterEmmanuel BarillotRaymond A. PootEdith HeardJoost GribnauNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Agnese Loda Johannes H. Brandsma Ivaylo Vassilev Nicolas Servant Friedemann Loos Azadeh Amirnasr Erik Splinter Emmanuel Barillot Raymond A. Poot Edith Heard Joost Gribnau Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
description	Xist RNA is required for X chromosome inactivation but it is not well understood how Xist silences some regions more efficiently than others. Here, the authors induce ectopic Xist expression from multiple different X-linked and autosomal loci in cells to explore Xist function.
format	article
author	Agnese Loda Johannes H. Brandsma Ivaylo Vassilev Nicolas Servant Friedemann Loos Azadeh Amirnasr Erik Splinter Emmanuel Barillot Raymond A. Poot Edith Heard Joost Gribnau
author_facet	Agnese Loda Johannes H. Brandsma Ivaylo Vassilev Nicolas Servant Friedemann Loos Azadeh Amirnasr Erik Splinter Emmanuel Barillot Raymond A. Poot Edith Heard Joost Gribnau
author_sort	Agnese Loda
title	Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
title_short	Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
title_full	Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
title_fullStr	Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
title_full_unstemmed	Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
title_sort	genetic and epigenetic features direct differential efficiency of xist-mediated silencing at x-chromosomal and autosomal locations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bead8e222125434f8fcd1ca116a4f245
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Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

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