Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations

Xist RNA is required for X chromosome inactivation but it is not well understood how Xist silences some regions more efficiently than others. Here, the authors induce ectopic Xist expression from multiple different X-linked and autosomal loci in cells to explore Xist function.

Guardado en:
Detalles Bibliográficos
Autores principales: Agnese Loda, Johannes H. Brandsma, Ivaylo Vassilev, Nicolas Servant, Friedemann Loos, Azadeh Amirnasr, Erik Splinter, Emmanuel Barillot, Raymond A. Poot, Edith Heard, Joost Gribnau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/bead8e222125434f8fcd1ca116a4f245
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares