Molecular basis for protection of ribosomal protein L4 from cellular degradation

Acl4 is a dedicated assembly chaperone for ribosomal protein RpL4 that recognizes RpL4 in the cytoplasm to facilitate its nuclear import. Here the authors reveal the mechanism whereby Acl4 recognizes RpL4 and functions to protect it from Tom1-mediated degradation until RpL4 incorporation into the ma...

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Autores principales:	Ferdinand M. Huber, André Hoelz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/beada90613c54f668801840fc617dc64
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spelling	oai:doaj.org-article:beada90613c54f668801840fc617dc642021-12-02T14:42:39ZMolecular basis for protection of ribosomal protein L4 from cellular degradation10.1038/ncomms143542041-1723https://doaj.org/article/beada90613c54f668801840fc617dc642017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14354https://doaj.org/toc/2041-1723Acl4 is a dedicated assembly chaperone for ribosomal protein RpL4 that recognizes RpL4 in the cytoplasm to facilitate its nuclear import. Here the authors reveal the mechanism whereby Acl4 recognizes RpL4 and functions to protect it from Tom1-mediated degradation until RpL4 incorporation into the maturing 60S pre-ribosomal subunit.Ferdinand M. HuberAndré HoelzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ferdinand M. Huber André Hoelz Molecular basis for protection of ribosomal protein L4 from cellular degradation
description	Acl4 is a dedicated assembly chaperone for ribosomal protein RpL4 that recognizes RpL4 in the cytoplasm to facilitate its nuclear import. Here the authors reveal the mechanism whereby Acl4 recognizes RpL4 and functions to protect it from Tom1-mediated degradation until RpL4 incorporation into the maturing 60S pre-ribosomal subunit.
format	article
author	Ferdinand M. Huber André Hoelz
author_facet	Ferdinand M. Huber André Hoelz
author_sort	Ferdinand M. Huber
title	Molecular basis for protection of ribosomal protein L4 from cellular degradation
title_short	Molecular basis for protection of ribosomal protein L4 from cellular degradation
title_full	Molecular basis for protection of ribosomal protein L4 from cellular degradation
title_fullStr	Molecular basis for protection of ribosomal protein L4 from cellular degradation
title_full_unstemmed	Molecular basis for protection of ribosomal protein L4 from cellular degradation
title_sort	molecular basis for protection of ribosomal protein l4 from cellular degradation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/beada90613c54f668801840fc617dc64
work_keys_str_mv	AT ferdinandmhuber molecularbasisforprotectionofribosomalproteinl4fromcellulardegradation AT andrehoelz molecularbasisforprotectionofribosomalproteinl4fromcellulardegradation
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Molecular basis for protection of ribosomal protein L4 from cellular degradation

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