Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei

Polyadenylation stabilizes edited mitochondrial mRNAs in Trypanosoma brucei, but the involved poly(A) binding protein is unknown. Here, Mesitov et al. show that a pentatricopeptide repeat factor KPAF4 binds to A-tail and prevents exonucleolytic degradation as well as translation of incompletely edit...

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Autores principales:	Mikhail V. Mesitov, Tian Yu, Takuma Suematsu, Francois M. Sement, Liye Zhang, Clinton Yu, Lan Huang, Inna Aphasizheva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/beb052ba41274537a91ad07c1ec9eb91
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spelling	oai:doaj.org-article:beb052ba41274537a91ad07c1ec9eb912021-12-02T14:35:37ZPentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei10.1038/s41467-018-08137-22041-1723https://doaj.org/article/beb052ba41274537a91ad07c1ec9eb912019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08137-2https://doaj.org/toc/2041-1723Polyadenylation stabilizes edited mitochondrial mRNAs in Trypanosoma brucei, but the involved poly(A) binding protein is unknown. Here, Mesitov et al. show that a pentatricopeptide repeat factor KPAF4 binds to A-tail and prevents exonucleolytic degradation as well as translation of incompletely edited mRNAs.Mikhail V. MesitovTian YuTakuma SuematsuFrancois M. SementLiye ZhangClinton YuLan HuangInna AphasizhevaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mikhail V. Mesitov Tian Yu Takuma Suematsu Francois M. Sement Liye Zhang Clinton Yu Lan Huang Inna Aphasizheva Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
description	Polyadenylation stabilizes edited mitochondrial mRNAs in Trypanosoma brucei, but the involved poly(A) binding protein is unknown. Here, Mesitov et al. show that a pentatricopeptide repeat factor KPAF4 binds to A-tail and prevents exonucleolytic degradation as well as translation of incompletely edited mRNAs.
format	article
author	Mikhail V. Mesitov Tian Yu Takuma Suematsu Francois M. Sement Liye Zhang Clinton Yu Lan Huang Inna Aphasizheva
author_facet	Mikhail V. Mesitov Tian Yu Takuma Suematsu Francois M. Sement Liye Zhang Clinton Yu Lan Huang Inna Aphasizheva
author_sort	Mikhail V. Mesitov
title	Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
title_short	Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
title_full	Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
title_fullStr	Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
title_full_unstemmed	Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
title_sort	pentatricopeptide repeat poly(a) binding protein kpaf4 stabilizes mitochondrial mrnas in trypanosoma brucei
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/beb052ba41274537a91ad07c1ec9eb91
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Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei

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