Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization

Abstract The gut microbiota could affect human health and disease. Although disease-associated microbiota alteration has been extensively investigated in the Chinese population, a nationwide Chinese gut microbiota baseline is still lacking. Here we performed 16 S rRNA gene sequencing on fecal sample...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jing Lu, Li Zhang, Qixiao Zhai, Jianxin Zhao, Hao Zhang, Yuan-Kun Lee, Wenwei Lu, Mingkun Li, Wei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/beb28c0f7aa04810b769309f09be9d95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:beb28c0f7aa04810b769309f09be9d95
record_format	dspace
spelling	oai:doaj.org-article:beb28c0f7aa04810b769309f09be9d952021-12-02T19:13:54ZChinese gut microbiota and its associations with staple food type, ethnicity, and urbanization10.1038/s41522-021-00245-02055-5008https://doaj.org/article/beb28c0f7aa04810b769309f09be9d952021-09-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00245-0https://doaj.org/toc/2055-5008Abstract The gut microbiota could affect human health and disease. Although disease-associated microbiota alteration has been extensively investigated in the Chinese population, a nationwide Chinese gut microbiota baseline is still lacking. Here we performed 16 S rRNA gene sequencing on fecal samples from 2678 healthy Chinese individuals, who belonged to eight ethnic groups and resided in 63 counties/cities of 28 provinces. We identified four enterotypes, three of which were enriched for Prevotella, Bacteroides, and Escherichia, respectively, whereas the fourth one had no dominant genus. By assessing the association between the gut microbiota and 20 variables belonging to six categories, geography, demography, diet, urbanization, lifestyle, and sampling month, we revealed that geography explained the largest microbiota variation, and clarified the distinct patterns in the associations with staple food type, ethnicity, and urban/rural residence. Specifically, the gut microbiota of Han Chinese and ethnic minority groups from the same sites was more alike than that of the same ethnic minority groups from different sites. Individuals consuming wheat as staple food were predicted to have more microbial genes involving in glucan 1,3-beta-glucosidase and S-adenosyl-l-methionine biosynthesis than those who consumed rice, based on functional prediction. Besides, an appreciable effect of urbanization on decreased intra-individual diversity, increased inter-individual diversity, and increased proportion of the Bacteroides enterotype was observed. Collectively, our study provided a nationwide gut microbiota baseline of the Chinese population and knowledge on important covariates, which are fundamental to translational microbiota research.Jing LuLi ZhangQixiao ZhaiJianxin ZhaoHao ZhangYuan-Kun LeeWenwei LuMingkun LiWei ChenNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Jing Lu Li Zhang Qixiao Zhai Jianxin Zhao Hao Zhang Yuan-Kun Lee Wenwei Lu Mingkun Li Wei Chen Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization
description	Abstract The gut microbiota could affect human health and disease. Although disease-associated microbiota alteration has been extensively investigated in the Chinese population, a nationwide Chinese gut microbiota baseline is still lacking. Here we performed 16 S rRNA gene sequencing on fecal samples from 2678 healthy Chinese individuals, who belonged to eight ethnic groups and resided in 63 counties/cities of 28 provinces. We identified four enterotypes, three of which were enriched for Prevotella, Bacteroides, and Escherichia, respectively, whereas the fourth one had no dominant genus. By assessing the association between the gut microbiota and 20 variables belonging to six categories, geography, demography, diet, urbanization, lifestyle, and sampling month, we revealed that geography explained the largest microbiota variation, and clarified the distinct patterns in the associations with staple food type, ethnicity, and urban/rural residence. Specifically, the gut microbiota of Han Chinese and ethnic minority groups from the same sites was more alike than that of the same ethnic minority groups from different sites. Individuals consuming wheat as staple food were predicted to have more microbial genes involving in glucan 1,3-beta-glucosidase and S-adenosyl-l-methionine biosynthesis than those who consumed rice, based on functional prediction. Besides, an appreciable effect of urbanization on decreased intra-individual diversity, increased inter-individual diversity, and increased proportion of the Bacteroides enterotype was observed. Collectively, our study provided a nationwide gut microbiota baseline of the Chinese population and knowledge on important covariates, which are fundamental to translational microbiota research.
format	article
author	Jing Lu Li Zhang Qixiao Zhai Jianxin Zhao Hao Zhang Yuan-Kun Lee Wenwei Lu Mingkun Li Wei Chen
author_facet	Jing Lu Li Zhang Qixiao Zhai Jianxin Zhao Hao Zhang Yuan-Kun Lee Wenwei Lu Mingkun Li Wei Chen
author_sort	Jing Lu
title	Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization
title_short	Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization
title_full	Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization
title_fullStr	Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization
title_full_unstemmed	Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization
title_sort	chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/beb28c0f7aa04810b769309f09be9d95
work_keys_str_mv	AT jinglu chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT lizhang chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT qixiaozhai chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT jianxinzhao chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT haozhang chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT yuankunlee chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT wenweilu chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT mingkunli chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization AT weichen chinesegutmicrobiotaanditsassociationswithstaplefoodtypeethnicityandurbanization
_version_	1718376993366474752

Chinese gut microbiota and its associations with staple food type, ethnicity, and urbanization

Ejemplares similares