Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo

Abstract Myelin elaborated by oligodendrocytes (OLs) in the central nervous system (CNS) is required for saltatory conduction of action potentials along neuronal axons. We found that TMEFF2, a transmembrane protein with EGF-like and two follistatin-like domains, is selectively expressed in different...

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Autores principales:	Hao Huang, Peng Teng, Ruyi Mei, Aifen Yang, Zunyi Zhang, Xiaofeng Zhao, Mengsheng Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/beb52d54ebb54ea4be3e43cd23feab8f
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spelling	oai:doaj.org-article:beb52d54ebb54ea4be3e43cd23feab8f2021-12-02T15:05:47ZTmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo10.1038/s41598-017-00407-12045-2322https://doaj.org/article/beb52d54ebb54ea4be3e43cd23feab8f2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00407-1https://doaj.org/toc/2045-2322Abstract Myelin elaborated by oligodendrocytes (OLs) in the central nervous system (CNS) is required for saltatory conduction of action potentials along neuronal axons. We found that TMEFF2, a transmembrane protein with EGF-like and two follistatin-like domains, is selectively expressed in differentiating/myelinating OLs. Previous studies showed that TMEFF2 is capable of binding to PDGFA, which plays important roles in the proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPCs). However, molecular and genetic analysis revealed that Tmeff2 is a weak binder of PDGFA, and not required for OL differentiation and myelin gene expression in vivo. Together, our data suggested that Tmeff2 is specifically upregulated in OLs, but dispensable for OL differentiation and maturation.Hao HuangPeng TengRuyi MeiAifen YangZunyi ZhangXiaofeng ZhaoMengsheng QiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao Huang Peng Teng Ruyi Mei Aifen Yang Zunyi Zhang Xiaofeng Zhao Mengsheng Qiu Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo
description	Abstract Myelin elaborated by oligodendrocytes (OLs) in the central nervous system (CNS) is required for saltatory conduction of action potentials along neuronal axons. We found that TMEFF2, a transmembrane protein with EGF-like and two follistatin-like domains, is selectively expressed in differentiating/myelinating OLs. Previous studies showed that TMEFF2 is capable of binding to PDGFA, which plays important roles in the proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPCs). However, molecular and genetic analysis revealed that Tmeff2 is a weak binder of PDGFA, and not required for OL differentiation and myelin gene expression in vivo. Together, our data suggested that Tmeff2 is specifically upregulated in OLs, but dispensable for OL differentiation and maturation.
format	article
author	Hao Huang Peng Teng Ruyi Mei Aifen Yang Zunyi Zhang Xiaofeng Zhao Mengsheng Qiu
author_facet	Hao Huang Peng Teng Ruyi Mei Aifen Yang Zunyi Zhang Xiaofeng Zhao Mengsheng Qiu
author_sort	Hao Huang
title	Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo
title_short	Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo
title_full	Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo
title_fullStr	Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo
title_full_unstemmed	Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo
title_sort	tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/beb52d54ebb54ea4be3e43cd23feab8f
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_version_	1718388730028359680

Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo

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